The PRP8 inteins in Cryptococcus are a source of phylogenetic and epidemiological information

被引：36

作者：

Butler, MI ^{[1
]}

Poulter, RTM ^{[1
]}

机构：

[1] Univ Otago, Dept Biochem, Dunedin, New Zealand

来源：

FUNGAL GENETICS AND BIOLOGY | 2005年 / 42卷 / 05期

基金：

英国惠康基金;

关键词：

intein; protein splicing; Cryptococcus; molecular type;

D O I：

10.1016/j.fgb.2005.01.011

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Only two nuclear encoded inteins have been described. The first, SceVMA, was found in a vacuolar ATPase gene of Saccharomyces cerevisiae and related yeasts. The second, CnePRP8, was found in the PRP8 gene of Cryptococcus neoformans. CnePRP8 contains protein sequences associated with intein splicing but no endonuclease domain. We compared allelic mini-inteins in both varieties of C. neoformans (var. neoformans and var. grubii) and in the related primary pathogen C gattii to study the evolution of both the mini-intein and the host. We also describe a full-length, endonuclease-contain in g intein in Cryptococcus laurentii, a moderately distant relation of C neoformans. We did not detect an intein in the PRP8 gene of other species of Cryptococcus including species closely related to the C neoformans/C gattii group. It is therefore probable that the C neoformans/C gattii mini-intein was derived from horizontal transfer in which C laurentii or another intein-containing species was the source. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：452 / 463

页数：12

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