The midbrain-hindbrain boundary organizer

被引：239

作者：

Rhinn, M ^{[1
]}

Brand, M ^{[1
]}

机构：

[1] Max Planck Inst Mol Cell Biol & Genet, D-01307 Dresden, Germany

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2001年 / 11卷 / 01期

关键词：

D O I：

10.1016/S0959-4388(00)00171-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cell fate in the cephalic neural primordium is controlled by an organizer located at the midbrain-hindbrain boundary. Studies in chick, mouse and zebrafish converge to show that mutually repressive interactions between homeodomain transcription factors of the Otx and Gbx class position this organizer in the neural primordium. Once positioned, independent signaling pathways converge in their activity to drive organizer function. Fibroblast growth factors secreted from the organizer are necessary for, and sufficient to mimic, organizer activity in patterning the midbrain and anterior hindbrain, and are tightly controlled by feedback inhibition.

引用

页码：34 / 42

页数：9

共 96 条

[1]

ACAMPORA D, 1995, DEVELOPMENT, V121, P3279

[2]

Acampora D, 1998, DEVELOPMENT, V125, P5091

[3]

Acampora D, 1997, DEVELOPMENT, V124, P3639

[4] INDUCTION AND AXIAL PATTERNING OF THE NEURAL PLATE - PLANAR AND VERTICAL SIGNALS [J].

ALTABA, AR .

JOURNAL OF NEUROBIOLOGY, 1993, 24 (10) :1276-1304

[5]

ANG SL, 1993, DEVELOPMENT, V118, P139

[6]

ANG SL, 1994, DEVELOPMENT, V120, P2979

[7]

Ang SL, 1996, DEVELOPMENT, V122, P243

[8] HNF-3-BETA IS ESSENTIAL FOR NODE AND NOTOCHORD FORMATION IN MOUSE DEVELOPMENT [J].

ANG, SL ;

ROSSANT, J .

CELL, 1994, 78 (04) :561-574

[9]

[Anonymous], MAMMALIAN DEV

[10] INVOLVEMENT OF WNT-1 IN THE FORMATION OF THE MES METENCEPHALIC BOUNDARY [J].

BALLYCUIF, L ;

CHOLLEY, B ;

WASSEF, M .

MECHANISMS OF DEVELOPMENT, 1995, 53 (01) :23-34

← 1 2 3 4 5 6 7 8 9 10 →