Hypotensive activity of aqueous extract of Andrographis paniculata in rats

被引：86

作者：

Zhang, CY ^{[1
]}

Tan, BKH ^{[1
]}

机构：

[1] NATL UNIV SINGAPORE, FAC MED, DEPT PHARMACOL, SINGAPORE 119260, SINGAPORE

来源：

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 1996年 / 23卷 / 08期

关键词：

Andrographis paniculata; angiotensin-converting enzyme; lipid peroxidation; spontaneously hypertensive rat; systolic blood pressure; Wistar-Kyoto rat;

D O I：

10.1111/j.1440-1681.1996.tb01756.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. The hypotensive activity of an aqueous extract of Andrographis paniculata was studied using chronic intraperitoneal (i.p.) infusions by osmotic pumps. The extract exhibited a dose-dependent hypotensive effect on the systolic blood pressure (SBP) of spontaneously hypertensive rats (SHR). 2. The optimum hypotensive dose determined was repeated in a study in SHR and their normotensive controls, Wistar-Kyoto (WKY) rats, to demonstrate its comparative effects on the SBP, plasma and lung angiotensin-converting enzyme (ACE) activities, as well as on lipid peroxidation in the kidneys, as measured by the thiobarbituric acid (TBA) assay. 3. The extract significantly lowered the SBP of both SHR and WKY rats. 4. Plasma, but not lung, ACE activity and kidney TBA level were significantly lower in extract-treated SHR when compared with vehicle-treated SHR controls. 5. Plasma and lung ACE activities as well as kidney TBA levels were not significantly different between extract- and vehicle-treated WKY rats. 6. This study indicates that the aqueous extract of A. paniculata lowers SBP in the SHR possibly by reducing circulating ACE in the plasma as well as by reducing free radical levels in the kidneys, The mechanism(s) of hypotensive action seems to be different in WKY rats.

引用

页码：675 / 678

页数：4

共 26 条

[1]

AHMAD M, 1993, INT C US TRAD MED OT, P122

[2]

AKBARSHA MA, 1990, INDIAN J EXP BIOL, V28, P421

[3]

ANTONACCIO MJ, 1990, CARDIOVASCULAR PHARM

[4] DIRECT SCAVENGING OF FREE-RADICALS BY CAPTOPRIL, AN ANGIOTENSIN CONVERTING ENZYME-INHIBITOR [J].

BAGCHI, D ;

PRASAD, R ;

DAS, DK .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 158 (01) :52-57

[5] VALIDATION IN AWAKE RATS OF A TAIL-CUFF METHOD FOR MEASURING SYSTOLIC PRESSURE [J].

BUNAG, RD .

JOURNAL OF APPLIED PHYSIOLOGY, 1973, 34 (02) :279-282

[6]

COHEN ML, 1982, J PHARMACOL EXP THER, V220, P63

[7]

Cushman D, 1972, HYPERTENSION 1972, P532

[8]

DAS UN, 1992, PROGR CLIN BIOCH, P889

[9] THE NATURE OF ENDOTHELIUM-DERIVED VASCULAR RELAXANT FACTOR [J].

GRIFFITH, TM ;

EDWARDS, DH ;

LEWIS, MJ ;

NEWBY, AC ;

HENDERSON, AH .

NATURE, 1984, 308 (5960) :645-647

[10] SUPEROXIDE ANION IS INVOLVED IN THE BREAKDOWN OF ENDOTHELIUM-DERIVED VASCULAR RELAXING FACTOR [J].

GRYGLEWSKI, RJ ;

PALMER, RMJ ;

MONCADA, S .

NATURE, 1986, 320 (6061) :454-456

← 1 2 3 →