共 25 条
Ligand-induced dimerization of Drosophila peptidoglycan recognition proteins in vitro
被引:87
作者:

Mellroth, P
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h-index: 0
机构: Univ Stockholm, Dept Genet Microbiol & Toxicol, S-10691 Stockholm, Sweden

Karlsson, J
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机构: Univ Stockholm, Dept Genet Microbiol & Toxicol, S-10691 Stockholm, Sweden

Håkansson, J
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h-index: 0
机构: Univ Stockholm, Dept Genet Microbiol & Toxicol, S-10691 Stockholm, Sweden

Schultz, N
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h-index: 0
机构: Univ Stockholm, Dept Genet Microbiol & Toxicol, S-10691 Stockholm, Sweden

Goldman, WE
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机构: Univ Stockholm, Dept Genet Microbiol & Toxicol, S-10691 Stockholm, Sweden

Steiner, H
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机构:
Univ Stockholm, Dept Genet Microbiol & Toxicol, S-10691 Stockholm, Sweden Univ Stockholm, Dept Genet Microbiol & Toxicol, S-10691 Stockholm, Sweden
机构:
[1] Univ Stockholm, Dept Genet Microbiol & Toxicol, S-10691 Stockholm, Sweden
[2] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA
来源:
关键词:
Imd/Relish;
innate immunity;
pattern recognition;
Toll/Dif;
D O I:
10.1073/pnas.0407559102
中图分类号:
O [数理科学和化学];
P [天文学、地球科学];
Q [生物科学];
N [自然科学总论];
学科分类号:
07 ;
0710 ;
09 ;
摘要:
Drosophila knockout mutants have placed peptidoglycan recognition proteins (PGRPs) in the two major pathways controlling immune gene expression. We now examine PGRP affinities for peptidoglycan. PGRP-SA and PGRP-LCx are bona fide pattern recognition receptors, and PGRP-SA, the peptidoglycan receptor of the Toll/Dif pathway, has selective affinity for different peptidoglycans. PGRP-LCx, the default peptidoglycan receptor of the Imd/Relish pathway, has strong affinity for all polymeric peptidoglycans tested and for monomeric peptidoglycan. PGRP-LCa does not have affinity for polymeric or monomeric peptidoglycan. Instead, PGRP-LCa can form heterodimers with LCx when the latter is bound to monomeric peptidoglycan. Hence, PGRP-LCa can be said to function as an adaptor, thus adding a new function to a member of the PGRP family.
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页码:6455 / 6460
页数:6
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