New levodopa sustained-release floating minitablets coated with insoluble acrylic polymer

The aim of this study was to develop a new coated multiple-unit sustained-release floating system that is able to float over an extended period of time. Levodopa was used as a model drug. The system consisted of a 3 mm drug-containing gas-generating core, prepared by melt granulation and subsequent compression, and coated with a flexible polymeric membrane. Eudragit (R) RL30D and ATEC were used as a film former and a plasticizer, respectively. The coating level was fixed at 20% (w/w). The floating lag time decreased as the proportion of effervescent agents increased. The optimized coated floating minitablets could float within 20 min and remained buoyant for more than 13 h. In addition, a sustained release of levodopa for more than 20 h was observed. (c) 2007 Elsevier B.V. All rights reserved.