Aims/hypothesis. Interleukin (IL)-18 is a cytokine primarily produced by macrophages and capable of inducing T lymphocyte synthesis of interferon (IFN)-gamma. An up-regulated synthesis of IFN-gamma with consequential Type I cytokine dominance has been repeatedly shown in Type I (insulin-dependent) diabetes mellitus and thought to be involved in its pathogenesis. Because increased production of IFN-gamma could be secondary to a dysregulated synthesis of IL-18, we compared the circulating levels of IL-18 in patients with newly diagnosed Type I diabetes with those of non-diabetic first-degree relatives and healthy control subjects. Methods. Serum samples were obtained from healthy control subjects, patients with newly diagnosed Type I diabetes, and their healthy first-degree relatives. The latter were subdivided into "low" and "high" risk prediabetics depending on whether they were negative or positive for two or more of the anti-pancreatic autoantibodies ICA, GAD, IA-2 and IAA. Serum levels of IL-18 were measured by solid-phase ELISA. Results. Interleukin (IL)-18 was above the detection limit of 25 pg/ml in 7 of 40 (17 %) healthy control subjects, in 5 of 35 (14 %) patients and in 3 of 30 (10 %) first-degree relatives at low risk of developing Type I diabetes. In contrast, IL-18 could be detected in 19 of 28 (68 %; p < 0.0001) relatives at high risk. The mean serum level of IL-18 was higher in these individuals when compared with the low-risk relatives, patients and control subjects. Conclusion/interpretation. IL-18 serum levels are increased selectively during the early, subclinical stage of Type I diabetes.
机构:
Linkoping Univ, Fac Hlth Sci, Div Paediat, Clin Res Ctr,Dept Hlth & Environm, S-58185 Linkoping, SwedenLinkoping Univ, Fac Hlth Sci, Div Paediat, Clin Res Ctr,Dept Hlth & Environm, S-58185 Linkoping, Sweden
Karlsson, MGE
Lawesson, SS
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Linkoping Univ, Fac Hlth Sci, Div Paediat, Clin Res Ctr,Dept Hlth & Environm, S-58185 Linkoping, SwedenLinkoping Univ, Fac Hlth Sci, Div Paediat, Clin Res Ctr,Dept Hlth & Environm, S-58185 Linkoping, Sweden
Lawesson, SS
Ludvigsson, J
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Linkoping Univ, Fac Hlth Sci, Div Paediat, Clin Res Ctr,Dept Hlth & Environm, S-58185 Linkoping, SwedenLinkoping Univ, Fac Hlth Sci, Div Paediat, Clin Res Ctr,Dept Hlth & Environm, S-58185 Linkoping, Sweden
机构:
Univ Colorado, Hlth Sci Ctr, Barbara Davis Ctr Childhood Diabet, Denver, CO 80262 USAUniv Colorado, Hlth Sci Ctr, Barbara Davis Ctr Childhood Diabet, Denver, CO 80262 USA
Redondo, MJ
Gottlieb, PA
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Univ Colorado, Hlth Sci Ctr, Barbara Davis Ctr Childhood Diabet, Denver, CO 80262 USAUniv Colorado, Hlth Sci Ctr, Barbara Davis Ctr Childhood Diabet, Denver, CO 80262 USA
Gottlieb, PA
Motheral, T
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Univ Colorado, Hlth Sci Ctr, Barbara Davis Ctr Childhood Diabet, Denver, CO 80262 USAUniv Colorado, Hlth Sci Ctr, Barbara Davis Ctr Childhood Diabet, Denver, CO 80262 USA
Motheral, T
Mulgrew, C
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Univ Colorado, Hlth Sci Ctr, Barbara Davis Ctr Childhood Diabet, Denver, CO 80262 USAUniv Colorado, Hlth Sci Ctr, Barbara Davis Ctr Childhood Diabet, Denver, CO 80262 USA
Mulgrew, C
Rewers, M
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Univ Colorado, Hlth Sci Ctr, Barbara Davis Ctr Childhood Diabet, Denver, CO 80262 USAUniv Colorado, Hlth Sci Ctr, Barbara Davis Ctr Childhood Diabet, Denver, CO 80262 USA
Rewers, M
Babu, S
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Univ Colorado, Hlth Sci Ctr, Barbara Davis Ctr Childhood Diabet, Denver, CO 80262 USAUniv Colorado, Hlth Sci Ctr, Barbara Davis Ctr Childhood Diabet, Denver, CO 80262 USA
Babu, S
Stephens, E
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Univ Colorado, Hlth Sci Ctr, Barbara Davis Ctr Childhood Diabet, Denver, CO 80262 USAUniv Colorado, Hlth Sci Ctr, Barbara Davis Ctr Childhood Diabet, Denver, CO 80262 USA
Stephens, E
Wegmann, DR
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Univ Colorado, Hlth Sci Ctr, Barbara Davis Ctr Childhood Diabet, Denver, CO 80262 USAUniv Colorado, Hlth Sci Ctr, Barbara Davis Ctr Childhood Diabet, Denver, CO 80262 USA
Wegmann, DR
Eisenbarth, GS
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Univ Colorado, Hlth Sci Ctr, Barbara Davis Ctr Childhood Diabet, Denver, CO 80262 USAUniv Colorado, Hlth Sci Ctr, Barbara Davis Ctr Childhood Diabet, Denver, CO 80262 USA
机构:
Linkoping Univ, Fac Hlth Sci, Div Paediat, Clin Res Ctr,Dept Hlth & Environm, S-58185 Linkoping, SwedenLinkoping Univ, Fac Hlth Sci, Div Paediat, Clin Res Ctr,Dept Hlth & Environm, S-58185 Linkoping, Sweden
Karlsson, MGE
Lawesson, SS
论文数: 0引用数: 0
h-index: 0
机构:
Linkoping Univ, Fac Hlth Sci, Div Paediat, Clin Res Ctr,Dept Hlth & Environm, S-58185 Linkoping, SwedenLinkoping Univ, Fac Hlth Sci, Div Paediat, Clin Res Ctr,Dept Hlth & Environm, S-58185 Linkoping, Sweden
Lawesson, SS
Ludvigsson, J
论文数: 0引用数: 0
h-index: 0
机构:
Linkoping Univ, Fac Hlth Sci, Div Paediat, Clin Res Ctr,Dept Hlth & Environm, S-58185 Linkoping, SwedenLinkoping Univ, Fac Hlth Sci, Div Paediat, Clin Res Ctr,Dept Hlth & Environm, S-58185 Linkoping, Sweden
机构:
Univ Colorado, Hlth Sci Ctr, Barbara Davis Ctr Childhood Diabet, Denver, CO 80262 USAUniv Colorado, Hlth Sci Ctr, Barbara Davis Ctr Childhood Diabet, Denver, CO 80262 USA
Redondo, MJ
Gottlieb, PA
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h-index: 0
机构:
Univ Colorado, Hlth Sci Ctr, Barbara Davis Ctr Childhood Diabet, Denver, CO 80262 USAUniv Colorado, Hlth Sci Ctr, Barbara Davis Ctr Childhood Diabet, Denver, CO 80262 USA
Gottlieb, PA
Motheral, T
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado, Hlth Sci Ctr, Barbara Davis Ctr Childhood Diabet, Denver, CO 80262 USAUniv Colorado, Hlth Sci Ctr, Barbara Davis Ctr Childhood Diabet, Denver, CO 80262 USA
Motheral, T
Mulgrew, C
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado, Hlth Sci Ctr, Barbara Davis Ctr Childhood Diabet, Denver, CO 80262 USAUniv Colorado, Hlth Sci Ctr, Barbara Davis Ctr Childhood Diabet, Denver, CO 80262 USA
Mulgrew, C
Rewers, M
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h-index: 0
机构:
Univ Colorado, Hlth Sci Ctr, Barbara Davis Ctr Childhood Diabet, Denver, CO 80262 USAUniv Colorado, Hlth Sci Ctr, Barbara Davis Ctr Childhood Diabet, Denver, CO 80262 USA
Rewers, M
Babu, S
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h-index: 0
机构:
Univ Colorado, Hlth Sci Ctr, Barbara Davis Ctr Childhood Diabet, Denver, CO 80262 USAUniv Colorado, Hlth Sci Ctr, Barbara Davis Ctr Childhood Diabet, Denver, CO 80262 USA
Babu, S
Stephens, E
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado, Hlth Sci Ctr, Barbara Davis Ctr Childhood Diabet, Denver, CO 80262 USAUniv Colorado, Hlth Sci Ctr, Barbara Davis Ctr Childhood Diabet, Denver, CO 80262 USA
Stephens, E
Wegmann, DR
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h-index: 0
机构:
Univ Colorado, Hlth Sci Ctr, Barbara Davis Ctr Childhood Diabet, Denver, CO 80262 USAUniv Colorado, Hlth Sci Ctr, Barbara Davis Ctr Childhood Diabet, Denver, CO 80262 USA
Wegmann, DR
Eisenbarth, GS
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado, Hlth Sci Ctr, Barbara Davis Ctr Childhood Diabet, Denver, CO 80262 USAUniv Colorado, Hlth Sci Ctr, Barbara Davis Ctr Childhood Diabet, Denver, CO 80262 USA