Protective effect of erythropoietin in neonatal hypoxic ischemia in mice

被引：72

作者：

Matsushita, H ^{[1
]}

Johnston, MV

Lange, MS

Wilson, MA

机构：

[1] Kennedy Krieger Res Inst, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Baltimore, MD 21205 USA

来源：

NEUROREPORT | 2003年 / 14卷 / 13期

关键词：

caspase-3; neuroprotection; NF kappa B;

D O I：

10.1097/00001756-200309150-00020

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of systemic erythropoietin pretreatment on hypoxic ischemic injury was examined in neonatal mice. Injury was significantly less in cortex, hippocampus, striatum and thalamus of erythropoietin-treated animals (5 U/g vs vehicle) 24 h after hypoxic ischemia and in all of these regions except hippocampus at 7 days. Activated caspase-3- and activated NFkappaB-immunoreactive neurons were observed in the injured areas; these areas were smaller in the erythropoietin group. To our knowledge, this is the first report demonstrating persistent neuroprotective effects of erythropoietin in neonatal mice. (C) 2003 Lippincott Williams Wilkins.

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收藏

页码：1757 / 1761

页数：5

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