The Mediterranean and Dietary Approaches to Stop Hypertension (DASH) diets and colorectal cancer

Background Although the Mediterranean diet has been studied for cancer mortality and the Dietary Approaches to Stop Hypertension (DASH) diet shares similarities with the Mediterranean diet few studies have specifically examined these 2 diets and incident colorectal cancer Objective The objective was to prospectively assess the association between the Alternate Mediterranean Diet (aMed) and the DASH style diet scores and risk of colorectal cancer in middle aged men and women Design A total of 87 256 women and 45 490 men (age 30-55 y for women and 40-75 y for men at baseline) without a history of cancer were followed for <= 26 y The aMed and DASH scores were calculated for each participant by using dietary information that was assessed <= 7 times during follow up Relative risks (RRs) for colorectal cancer were computed with adjustment for potential confounders Results We documented 1432 cases of incident colorectal cancer among women and 1032 cases in men Comparing top with bottom quintiles of the DASH score the pooled RR for total colorectal cancer was 080 (95% CI 0 70 0 91 P for trend = 0 0001) The corresponding RR for DASH score and colon cancer was 081 (95% CI 0 69 0 95 P for trend = 0 002) There was a suggestion of an inverse association with rectal cancer with a pooled RR-of 0 73 (95% CI 0 55 0 98 P for trend = 0 31) when comparing top with bottom quintiles of DASH score No association was observed with aMed score Conclusion Adherence to the DASH diet (which involves higher intakes of whole grains fruit and vegetables moderate amounts of low fat dairy and lower amounts of red or processed meats desserts and sweetened beverages) was associated with a lower risk of colorectal cancer Am J Clin Nutr 2010 92 1429-35