Hyponatremia and sensorineural hearing loss in preterm infants

被引:33
作者
Ertl, T
Hadzsiev, K
Vincze, O
Pytel, J
Szabo, I
Sulyok, E
机构
[1] Country Childrens Hosp, H-7601 Pecs, Hungary
[2] Univ Pecs, Fac Med, Dept Otorhinolaryngol, Pecs, Hungary
[3] Univ Pecs, Fac Med, Dept Obstet & Gynecol, Pecs, Hungary
来源
BIOLOGY OF THE NEONATE | 2001年 / 79卷 / 02期
关键词
hyponatremia; sensorineural hearing loss; preterm infant;
D O I
10.1159/000047076
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
In a case-control study the role of hyponatremia in the hearing loss of preterm infants was investigated. One hundred and sixty-four premature infants treated at the neonatal intensive care unit were screened with transient evoked otoacoustic emission (TEAOE). In 32 infants TEAOE results indicated the need for further investigations. Auditory brainstem response was performed and 22 of 32 cases had bilateral hearing impairment (HI). The birth weight and gestational age in the HI group were 1,425 +/- 528 g and 30.4 +/- 3.7 weeks. The matched control group consisted of 25 infants with a mean birth weight and gestational age of 1,410 +/- 280 g and 31.1 +/- 2.1 weeks. Significant differences were found between the HI and control groups: Apgar score (p < 0.05), pH value (p < 0.01) and pO(2) level (p < 0.05) were lower; the total dose of aminoglycosides (p < 0.01), furosemide usage (p < 0.01), the maxim um pCO(2) level (p < 0.01), incubator stay (p < 0.05) and hyponatremia (p < 0.01)were higher, and the duration of hyponatremia (p < 0.05) was longer in the HI group. Multivariate logistic regression revealed that aminoglycoside treatment and hyponatremia were the two most significant factors in the development of hearing impairment. These results suggest that hyponatraemia is an additional risk factor for hearing loss in preterm infants. Copyright (C) 2001 S. Karger AG, Basel.
引用
收藏
页码:109 / 112
页数:4
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