Pharmacokinetic profile of topiramate in comparison with other new antiepileptic drugs

被引：39

作者：

Perucca, E ^{[1
]}

机构：

[1] UNIV PAVIA, DEPT MED & THERAPEUT, CLIN PHARMACOL UNIT, DIV PHARMACOL & TOXICOL, PAVIA, ITALY

来源：

EPILEPSIA | 1996年 / 37卷

关键词：

epilepsy; anticonvulsants; pharmacokinetics; interactions; topiramate; seizures; adverse events;

D O I：

10.1111/j.1528-1157.1996.tb06032.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Antiepileptic drugs (AEDs)in broad use today have a number of pharmacokinetic liabilities, including a propensity for clinically meaningful drug interactions. Therefore, new AEDs with improved pharmacokinetic characteristics would be welcomed. The pharmacokinetic profiles of six newer AEDs-topiramate (TPM), gabapentin (GBP), vigabatrin (VGB), lamotrigine (LTG), oxcarbazepine (OCBZ), and felbamate-were reviewed. Some of these AEDs offer an improvement in one or more pharmacokinetic parameters compared with traditional AEDs, with TPM, GBP, VGB, and OCBZ demonstrating the most advantageous overall pharmacokinetic profiles.

引用

页码：S8 / S13

页数：6

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