A novel function for Myc: Inhibition of C/EBP-dependent gene activation

被引：57

作者：

Mink, S ^{[1
]}

Mutschler, B ^{[1
]}

Weiskirchen, R ^{[1
]}

Bister, K ^{[1
]}

Klempnauer, KH ^{[1
]}

机构：

[1] UNIV INNSBRUCK, INST BIOCHEM, A-6020 INNSBRUCK, AUSTRIA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1996年 / 93卷 / 13期

关键词：

v-myc oncogene; C/EBP transcription factors; myelomonocytic cells; signal transduction;

D O I：

10.1073/pnas.93.13.6635

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We have investigated the effect of the v-Myc oncoprotein on gene expression In myelomonocytic cells. We find that v-Myc dramatically down-regulates the expression of myelomonocytic-specific genes, such as the chicken mim-1 and lysozyme genes, both of which are known targets for C/EBP transcription factors. We present evidence that Myc down-regulates these genes by inhibiting the function of C/EBP transcription factors. Detailed examination of the inhibitory mechanism shows that amino-terminal sequences of v-Myc, but not its DNA-binding domain, are required for the suppression of C/EBP-dependent transactivation. Our findings Identify a new function for Myc and reveal a novel mechanism by which MSc affects the expression of other genes.

引用

页码：6635 / 6640

页数：6

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