ATM: the p53 booster

被引：34

作者：

Nakamura, Y ^{[1
]}

机构：

[1] Univ Tokyo, Inst Med Sci, Ctr Human Genome, Mol Med Lab, Tokyo, Japan

来源：

NATURE MEDICINE | 1998年 / 4卷 / 11期

关键词：

D O I：

10.1038/3207

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ATM gene (mutated in the disease ataxia telangiectasia) activates the p53 tumor suppressor protein in response to DNA damage, explaining the higher incidence of cancer in AT patients.

引用

页码：1231 / 1232

页数：2

共 10 条

[1] Enhanced phosphorylation of p53 by ATN in response to DNA damage [J].

Banin, S ;

Moyal, L ;

Shieh, SY ;

Taya, Y ;

Anderson, CW ;

Chessa, L ;

Smorodinsky, NI ;

Prives, C ;

Reiss, Y ;

Shiloh, Y ;

Ziv, Y .

SCIENCE, 1998, 281 (5383) :1674-1677

[2] Activation of the ATM kinase by ionizing radiation and phosphorylation of p53 [J].

Canman, CE ;

Lim, DS ;

Cimprich, KA ;

Taya, Y ;

Tamai, K ;

Sakaguchi, K ;

Appella, E ;

Kastan, MB ;

Siliciano, JD .

SCIENCE, 1998, 281 (5383) :1677-1679

[3] A MAMMALIAN-CELL CYCLE CHECKPOINT PATHWAY UTILIZING P53 AND GADD45 IS DEFECTIVE IN ATAXIA-TELANGIECTASIA [J].

KASTAN, MB ;

ZHAN, QM ;

ELDEIRY, WS ;

CARRIER, F ;

JACKS, T ;

WALSH, WV ;

PLUNKETT, BS ;

VOGELSTEIN, B ;

FORNACE, AJ .

CELL, 1992, 71 (04) :587-597

[4] p53 is phosphorylated by CDK7-cyclin H in a p36(MAT1)-dependent manner [J].

Ko, LJ ;

Shieh, SY ;

Chen, XB ;

Jayaraman, L ;

Tamai, K ;

Taya, Y ;

Prives, C ;

Pan, ZQ .

MOLECULAR AND CELLULAR BIOLOGY, 1997, 17 (12) :7220-7229

[5] Ultraviolet radiation, but not γ radiation or etoposide-induced DNA damage, results in the phosphorylation of the murine p53 protein at serine-389 [J].

Lu, H ;

Taya, Y ;

Ikeda, M ;

Levine, AJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (11) :6399-6402

[6] A SINGLE ATAXIA-TELANGIECTASIA GENE WITH A PRODUCT SIMILAR TO PI-3 KINASE [J].

SAVITSKY, K ;

BARSHIRA, A ;

GILAD, S ;

ROTMAN, G ;

ZIV, Y ;

VANAGAITE, L ;

TAGLE, DA ;

SMITH, S ;

UZIEL, T ;

SFEZ, S ;

ASHKENAZI, M ;

PECKER, I ;

FRYDMAN, M ;

HARNIK, R ;

PATANJALI, SR ;

SIMMONS, A ;

CLINES, GA ;

SARTIEL, A ;

GATTI, RA ;

CHESSA, L ;

SANAL, O ;

LAVIN, MF ;

JASPERS, NGJ ;

MALCOLM, A ;

TAYLOR, R ;

ARLETT, CF ;

MIKI, T ;

WEISSMAN, SM ;

LOVETT, M ;

COLLINS, FS ;

SHILOH, Y .

SCIENCE, 1995, 268 (5218) :1749-1753

[7] THE COMPLETE SEQUENCE OF THE CODING REGION OF THE ATM GENE REVEALS SIMILARITY TO CELL-CYCLE REGULATORS IN DIFFERENT SPECIES [J].

SAVITSKY, K ;

SFEZ, S ;

TAGLE, DA ;

ZIV, Y ;

SARTIEL, A ;

COLLINS, FS ;

SHILOH, Y ;

ROTMAN, G .

HUMAN MOLECULAR GENETICS, 1995, 4 (11) :2025-2032

[8] DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2 [J].

Shieh, SY ;

Ikeda, M ;

Taya, Y ;

Prives, C .

CELL, 1997, 91 (03) :325-334

[9] ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins [J].

Waterman, MJF ;

Stavridi, ES ;

Waterman, JLF ;

Halazonetis, TD .

NATURE GENETICS, 1998, 19 (02) :175-178

[10] DNA-dependent protein kinase acts upstream of p53 in response to DNA damage [J].

Woo, RA ;

McLure, KG ;

Lees-Miller, SP ;

Rancourt, DE ;

Lee, PWK .

NATURE, 1998, 394 (6694) :700-704

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