Micromachine-Enabled Capture and Isolation of Cancer Cells in Complex Media

被引：333

作者：

Balasubramanian, Shankar ^{[1
]}

Kagan, Daniel ^{[1
]}

Hu, Che-Ming Jack ^{[1
]}

Campuzano, Susana ^{[1
]}

Lobo-Castanon, M. Jesus ^{[1
]}

Lim, Nicole ^{[1
]}

Kang, Dae Y. ^{[1
]}

Zimmerman, Maria ^{[1
]}

Zhang, Liangfang ^{[1
]}

Wang, Joseph ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept NanoEngn, La Jolla, CA 92093 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 18期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

antibodies; cancer; micromachines; CIRCULATING TUMOR-CELLS; COLLOIDAL CARGO; NANOMOTORS; TRANSPORT; DELIVERY; MOTION; BLOOD;

D O I：

10.1002/anie.201100115

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Microrockets detect cancer: A micromachine is used for the in vitro isolation of pancreatic cancer cells in complex media. The strategy is based on the selective binding and transport ability of antibody-functionalized microengine rockets: these microrockets selectively recognize the surface antigens overexpressed by pancreatic cancer cells, and capture and transport the cancer cells over a preselected path (see picture). Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：4161 / 4164

页数：4

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