Osteoprotegerin, a crucial regulator of bone metabolism, also regulates B cell development and function

被引：153

作者：

Yun, TJ

Tallquist, MD

Aicher, A

Rafferty, KL

Marshall, AJ

Moon, JJ

Ewings, MK

Mohaupt, M

Herring, SW

Clark, EA ^{[1
]}

机构：

[1] Univ Washington, Reg Primate Res Ctr, Dept Microbiol, Seattle, WA 98195 USA

[2] Univ Washington, Dept Immunol, Seattle, WA 98195 USA

[3] Univ Washington, Dept Orthodont, Seattle, WA 98195 USA

[4] Fred Hutchinson Canc Res Ctr, Div Basic Sci, Seattle, WA 98104 USA

[5] Fred Hutchinson Canc Res Ctr, Program Dev Biol, Seattle, WA 98104 USA

[6] Max Delbruck Ctr Mol Med, Berlin, Germany

来源：

JOURNAL OF IMMUNOLOGY | 2001年 / 166卷 / 03期

关键词：

D O I：

10.4049/jimmunol.166.3.1482

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Osteoprotegerin (OPG) is a CD40-regulated gene in B cells and dendritic cells (DCs). We investigated the role of OPG in the immune system by generating opg(-/-) mice. Like its role as a regulator of bone metabolism, OPG also influences processes in the immune system, notably in B cell development. Ex vivo, opg(-/-) pro-B cells have enhanced proliferation to IL-7, and in opg(-/-) spleen, there is an accumulation of type 1 transitional B cells. Furthermore, opg(-/-) bone marrow-derived DCs are more effective in stimulating allogeneic T cells than control DCs. When challenged with a T-dependent Ag, opg(-/-) mice had a compromised ability to sustain an IgG3 Ag-specific response. Thus, in the immune system, OPG regulates B cell maturation and development of efficient Ab responses.

引用

页码：1482 / 1491

页数：10

共 46 条

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