Reliability of the Roenigk classification of liver damage after methotrexate treatment for psoriasis

被引：27

作者：

Berends, Maartje A. M. ^{[1
]}

van Oijen, Martijn G. H. ^{[2
]}

Snoek, Josje ^{[2
]}

de Kerkhof, Peter C. M. van

Drenth, Joost P. H. ^{[2
]}

van Krieken, J. Han ^{[3
]}

de Jong, Elke M. G. J. ^{[1
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Dept Dermatol, NL-6525 GL Nijmegen, Netherlands

[2] Radboud Univ Nijmegen, Med Ctr, Dept Gastroenterol & Hepatol, NL-6525 GL Nijmegen, Netherlands

[3] Radboud Univ Nijmegen, Med Ctr, Dept Pathol, NL-6525 GL Nijmegen, Netherlands

来源：

ARCHIVES OF DERMATOLOGY | 2007年 / 143卷 / 12期

关键词：

D O I：

10.1001/archderm.143.12.1515

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Objective: To determine the interobserver reliability of the Roenigk score as a classification system of liver damage and its possible consequences for clinical practice. Design: Retrospective study. Setting: Academic research. Patients: One hundred sixty liver biopsy specimens from patients with psoriasis receiving methotrexate treatment were rereviewed and analyzed blindly by an experienced pathologist with an interest in liver pathologic conditions. Main Outcome Measure: Interobserver variation was evaluated using K statistics. Results: A high concordance was present in the evaluation of the Roenigk grade of fibrosis (weighted kappa=0.73; 95% confidence interval, 0.63-0.83). Agreement was good regarding the number of biopsy specimens for patients whose clinical management should be changed (kappa=0.71; 95% confidence interval, 0.56-0.87). Conclusion: The Roenigk classification in the assessment of liver fibrosis is a reliable scoring system.

引用

页码：1515 / 1519

页数：5

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