Enhanced expression of fractalkine in HIV-1 associated dementia

被引：68

作者：

Pereira, CF

Middel, J

Jansen, G

Verhoef, J

Nottet, HSLM

机构：

[1] Univ Utrecht, Med Ctr, Eijkman Winkler Inst, Neuroimmunol Sect, NL-3584 CX Utrecht, Netherlands

[2] Univ Utrecht, Med Ctr, Dept Pathol, Neuropathol Sect, NL-3584 CX Utrecht, Netherlands

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2001年 / 115卷 / 1-2期

关键词：

fractalkine; HIV-1 associated dementia; monocyte-derived macrophages; primary human astrocytes; reverse transcriptase-polymerase chain reaction; immunohistochemistry;

D O I：

10.1016/S0165-5728(01)00262-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The CX3C chemokine fractalkine was found to be up-regulated in the brain during inflammatory processes. In this study, we tried to assess the role of fractalkine in HIV-1-associated dementia. Fractalkine expression is up-regulated in the brains of AIDS patients with HAD. Fractalkine immunoreactivity was mainly detected in astrocytes. in addition, fractalkine expression was found to be up-regulated in cocultures of astrocytes and HIV infected macrophages. This up-regulation was dependent on cell-cell contact. We propose that fractalkine produced during interactions between astrocytes and HIV-infected macrophages plays a role in HAD by regulating the trafficking of monocytic cells in the brain parenchyma. (C) 2001 Elsevier Science B.V. All rights reserved.

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页码：168 / 175

页数：8

相关论文

共 27 条

[1] A new class of membrane-bound chemokine with a CX(3)C motif [J].

Bazan, JF ;

Bacon, KB ;

Hardiman, G ;

Wang, W ;

Soo, K ;

Rossi, D ;

Greaves, DR ;

Zlotnik, A ;

Schall, TJ .

NATURE, 1997, 385 (6617) :640-644

[2]

Boven LA, 1999, J IMMUNOL, V162, P4319

[3]

Boven LA, 1999, FEMS IMMUNOL MED MIC, V26, P243, DOI 10.1111/j.1574-695X.1999.tb01395.x

[4] Fractalkine cleavage from neuronal membranes represents an acute event in the inflammatory response to excitotoxic brain damage [J].

Chapman, GA ;

Moores, K ;

Harrison, D ;

Campbell, CA ;

Stewart, BR ;

Strijbos, PJLM .

JOURNAL OF NEUROSCIENCE, 2000, 20 (15)

[5] Identification of CX3CR1 -: A chemotactic receptor for the human CX3C chemokine fractalkine and a fusion coreceptor for HIV-1 [J].

Combadiere, C ;

Salzwedel, K ;

Smith, ED ;

Tiffany, HL ;

Berger, EA ;

Murphy, PM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (37) :23799-23804

[6] Induction of monocyte chemoattractant protein-1 in HIV-1 Tat-stimulated astrocytes and elevation in AIDS dementia [J].

Conant, K ;

Garzino-Demo, A ;

Nath, A ;

McArthur, JC ;

Halliday, W ;

Power, C ;

Gallo, RC ;

Major, EO .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (06) :3117-3121

[7] Identification of a major co-receptor for primary isolates of HIV-1 [J].

Deng, HK ;

Liu, R ;

Ellmeier, W ;

Choe, S ;

Unutmaz, D ;

Burkhart, M ;

DiMarzio, P ;

Marmon, S ;

Sutton, RE ;

Hill, CM ;

Davis, CB ;

Peiper, SC ;

Schall, TJ ;

Littman, DR ;

Landau, NR .

NATURE, 1996, 381 (6584) :661-666

[8] HIV-1 entry into CD4(+) cells is mediated by the chemokine receptor CC-CKR-5 [J].

Dragic, T ;

Litwin, V ;

Allaway, GP ;

Martin, SR ;

Huang, YX ;

Nagashima, KA ;

Cayanan, C ;

Maddon, PJ ;

Koup, RA ;

Moore, JP ;

Paxton, WA .

NATURE, 1996, 381 (6584) :667-673

[9] Rapid progression to AIDS in HIV+ individuals with a structural variant of the chemokine receptor CX3CR1 [J].

Faure, S ;

Meyer, L ;

Costagliola, D ;

Vaneensberghe, C ;

Genin, E ;

Autran, B ;

Delfraissy, JF ;

McDermott, DH ;

Murphy, PM ;

Debré, P ;

Théodorou, I ;

Combadière, C .

SCIENCE, 2000, 287 (5461) :2274-2277

[10] HIV-1 Entry Cofactor: Functional cDNA Cloing of a Seven-Transmembrane, G protein-Coupled Receptor [J].

Feng, Yu ;

Broder, Christopher C. ;

Kennedy, Paul E. ;

Berger, Edward A. .

JOURNAL OF IMMUNOLOGY, 2011, 186 (11) :872-877