PLGA nanoparticles containing praziquantel: effect of formulation variables on size distribution

被引：404

作者：

Mainardes, RM ^{[1
]}

Evangelista, RC ^{[1
]}

机构：

[1] UNESP, Programa Posgrad Ciencias Farmaceut, BR-14802902 Araraquara, SP, Brazil

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2005年 / 290卷 / 1-2期

关键词：

nanoparticles; controlled release; PLGA; praziquantel; emulsification evaporation method;

D O I：

10.1016/j.ijpharm.2004.11.027

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Praziquantel has been shown to be highly effective against all known species of Schistosoma infecting humans. Spherical nanoparticulate drug carriers made of poly(D,L-lactide-co-glycolide) acid with controlled size were designed. Praziquantel, a hydrophobic molecule, was entrapped into the nanoparticles with theoretical loading varying from 10 to 30% (w/w). This investigates the effects of some process variables on the size distribution of nanoparticles prepared by emulsion-solvent evaporation method. The results show that sonication time, PLGA and drug amounts, PVA concentration, ratio between aqueous and organic phases, and the method of solvent evaporation have a significant influence on size distribution of the nanoparticles. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：137 / 144

页数：8

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