DNA methylation in endometrial cancer

被引：62

作者：

Tao, Meng Hua ^{[1
]}

Freudenheim, Jo L. ^{[1
]}

机构：

[1] SUNY Buffalo, Dept Social & Prevent Med, Sch Publ Hlth & Hlth Profess, Buffalo, NY 14260 USA

来源：

EPIGENETICS | 2010年 / 5卷 / 06期

关键词：

DNA methylation; endometrial cancer; epidemiology; TUMOR-SUPPRESSOR GENE; MISMATCH REPAIR GENES; HMLH1 PROMOTER HYPERMETHYLATION; ESTROGEN-RECEPTOR GENE; DE-NOVO METHYLATION; MICROSATELLITE INSTABILITY; DOWN-REGULATION; PROGESTERONE-RECEPTOR; BREAST-CANCER; BETA-CATENIN;

D O I：

10.4161/epi.5.6.12431

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Endometrial cancer is the most commonly diagnosed gynecological cancer, and it has been shown to be a complex disease driven by abnormal genetic and epigenetic alterations, as well as environmental factors. Epigenetic changes resulting in aberrant gene expression are dynamic and modifiable features of many cancer types. A significant epigenetic change is aberrant DNA methylation. In this review, we review evidence on the role of aberrant DNA methylation, examining changes in relation to endometrial carcinogenesis, and report on recent advances in the understanding of the contribution of aberrant DNA methylation to endometrial cancer with the emphasis on the role of dietary/lifestyle and environmental factors, as well as opportunities and challenges of DNA methylation in endometrial cancer management and prevention.

引用

页码：491 / 498

页数：8

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