Ventricular enlargement in schizophrenia: a primary change in the temporal lobe?

被引：32

作者：

Chance, SA ^{[1
]}

Esiri, MM ^{[1
]}

Crow, TJ ^{[1
]}

机构：

[1] Univ Oxford, Oxford OX1 2JD, England

来源：

SCHIZOPHRENIA RESEARCH | 2003年 / 62卷 / 1-2期

基金：

英国医学研究理事会;

关键词：

schizophrenia; ventricles; parahippocampal; sex; gyrus; temporal;

D O I：

10.1016/S0920-9964(02)00344-4

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Background: The anatomical origin of the enlargement of the cerebral ventricles in schizophrenia is obscure. Methods: In this study, the volumes of the hemispheres and lateral ventricles were assessed in MRI scans of 43 formalin-fixed brains (23 from patients and 19 comparison subjects) using a spline 'snake' segmentation method. Results: A bilateral ventricular volume increase was found in schizophrenia. Whereas enlargement of the lateral ventricle (mean: 54%) as a whole was related to age of onset and was greater in females than in males, enlargement of the temporal horn (mean: 54%) was not strongly related to age of onset or sex. Lateral ventricle volume was negatively correlated with STG, fusiform and parahippocampal volume in schizophrenia. Hemispheric volumes were unchanged. Conclusions: The differing correlates of the components of ventricular enlargement suggest a degree of selectivity of the disease process with a focus in the temporal lobe. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：123 / 131

页数：9

共 48 条

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