Translocation (10;11)(p13;q13) and MLL gene rearrangement in a case of AML (M5a) with aggressive leukemia cutis

被引：15

作者：

Kubonishi, I ^{[1
]}

Seto, M

Murata, N

Kamioka, M

Taguchi, H

Miyoshi, I

机构：

[1] Kochi Med Sch, Dept Med, Nankoku, Kochi 783, Japan

[2] Aichi Canc Ctr, Res Inst, Lab Chemotherapy, Nagoya, Aichi 464, Japan

来源：

CANCER GENETICS AND CYTOGENETICS | 1998年 / 104卷 / 01期

关键词：

D O I：

10.1016/S0165-4608(97)00414-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A male patient with a secondary acute monocytic leukemia whose leukemia cells had a t(10;11)(p13;q13) chromosomal abnormality is described. Gene analysis disclosed that the patient's leukemia cells had MLL gene rearrangement. His leukemia cells responded poorly to chemotherapy, and the patient developed an unusual aggressive leukemia cutis. A t(10;11)(p13;q13) chromosomal abnormality that expresses MLL gene rearrangement has not been reported previously in secondary leukemia. (C) Elsevier Science Inc., 1998.

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页码：28 / 31

页数：4

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