Emerging role of RAB GTPases in cancer and human disease

被引：180

作者：

Cheng, KW

Lahad, JP

Gray, JW

Mills, GB

机构：

[1] Univ Texas, MD Anderson Canc Ctr, Dept Mol Therapeut, Houston, TX 77054 USA

[2] Univ Calif Berkeley, Lawrence Berkeley Lab, Berkeley, CA 94720 USA

来源：

CANCER RESEARCH | 2005年 / 65卷 / 07期

关键词：

D O I：

10.1158/0008-5472.CAN-05-0573

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Emerging evidence implicates alterations in the RAB small GTPases and their associated regulatory proteins and effectors in multiple human diseases including cancer. We have recently shown that RAB25, located at chromosome 1q22, is amplified at the DNA level and overexpressed at the RNA level in ovarian and breast cancer. These changes correlated with a worsened outcome in both diseases. In addition, enforced expression of RAB25 in both breast and ovarian cancer cells decreased apoptosis and increased proliferation and aggressiveness in vivo, potentially explaining the worsened prognosis. A better understanding of genetic alterations as well as the physiologic and pathophysiologic roles of RAB GTPases may open new opportunities for therapeutic intervention and better outcomes.

引用

收藏

页码：2516 / 2519

页数：4

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