Within-subject variability of BOLD response dynamics

被引:68
作者
Neumann, J [1 ]
Lohmann, G [1 ]
Zysset, S [1 ]
von Cramon, DY [1 ]
机构
[1] Max Planck Inst Cognit Neurosci, D-04103 Leipzig, Germany
关键词
D O I
10.1016/S1053-8119(03)00177-0
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
this paper we investigate the within-subject variability of dynamical aspects of the BOLD response obtained in a series of fMRI sessions several days apart. Five different parameters describing the temporal behavior of trial-averaged time courses, such as time-to-peak and time-to-onset, were estimated and analyzed with respect to their variability across nine sessions. Results show that small variances of the estimated parameters can be found, provided that the analysis is restricted to voxels activated in all individual sessions. Among the investigated parameters, time-to-peak shows the most stable behavior. These results were obtained using two different analysis methods, the estimation of the parameters directly from trial-averaged time courses and fitting trial-averaged time courses to an assumed hemodynamic response function. Both methods yield comparable results. (C) 2003 Elsevier Science (USA). All rights reserved.
引用
收藏
页码:784 / 796
页数:13
相关论文
共 52 条
[1]   The variability of human, BOLD hemodynamic responses [J].
Aguirre, GK ;
Zarahn, E ;
D'Esposito, M .
NEUROIMAGE, 1998, 8 (04) :360-369
[2]   DYNAMIC MAPPING OF THE HUMAN VISUAL-CORTEX BY HIGH-SPEED MAGNETIC-RESONANCE-IMAGING [J].
BLAMIRE, AM ;
OGAWA, S ;
UGURBIL, K ;
ROTHMAN, D ;
MCCARTHY, G ;
ELLERMANN, JM ;
HYDER, F ;
RATTNER, Z ;
SHULMAN, RG .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (22) :11069-11073
[3]   Linear systems analysis of functional magnetic resonance imaging in human V1 [J].
Boynton, GM ;
Engel, SA ;
Glover, GH ;
Heeger, DJ .
JOURNAL OF NEUROSCIENCE, 1996, 16 (13) :4207-4221
[4]   Functional-anatomic study of episodic retrieval II. Selective averaging of event-related fMRI trials to test the retrieval success hypothesis [J].
Buckner, RL ;
Koutstaal, W ;
Schacter, DL ;
Dale, AM ;
Rotte, M ;
Rosen, BR .
NEUROIMAGE, 1998, 7 (03) :163-175
[5]  
Buckner RL, 1998, HUM BRAIN MAPP, V6, P373, DOI 10.1002/(SICI)1097-0193(1998)6:5/6<373::AID-HBM8>3.0.CO
[6]  
2-P
[7]   Detection of cortical activation during averaged single trials of a cognitive task using functional magnetic resonance imaging [J].
Buckner, RL ;
Bandettini, PA ;
OCraven, KM ;
Savoy, RL ;
Petersen, SE ;
Raichle, ME ;
Rosen, BR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (25) :14878-14883
[8]   Parametric analysis of fMRI data using linear systems methods [J].
Cohen, MS .
NEUROIMAGE, 1997, 6 (02) :93-103
[9]   FUNCTIONAL MAGNETIC-RESONANCE-IMAGING (FMRI) OF THE HUMAN BRAIN [J].
DEYOE, EA ;
BANDETTINI, P ;
NEITZ, J ;
MILLER, D ;
WINANS, P .
JOURNAL OF NEUROSCIENCE METHODS, 1994, 54 (02) :171-187
[10]   Single-trial variability in event-related BOLD signals [J].
Duann, JR ;
Jung, TP ;
Kuo, WJ ;
Yeh, TC ;
Makeig, S ;
Hsieh, JC ;
Sejnowski, TJ .
NEUROIMAGE, 2002, 15 (04) :823-835