Ninjurin 1 asp110ala single nucleotide polymorphism is associated with protection in leprosy nerve damage

被引：26

作者：

Cardoso, Cynthia Chester

Martinez, Alejandra Nobrega

Guimaraes, Pedro Edson Moreira

Mendes, Camila Teixeira

Pacheco, Antonio Guilherme

de Oliveira, Rosane Barbosa

Brandao Teles, Rosane Magda

Illarramendi, Ximena

Sampaio, Elizabeth Pereira

Sarno, Euzenir Nunes

Dias-Neto, Emmanuel

Moraes, Milton Ozorio

机构：

[1] Fiocruz MS, Inst Oswaldo Cruz, Leprosy Lab, Mycobacterioses Dept, BR-21040360 Rio De Janeiro, Brazil

[2] Univ Sao Paulo, Inst & Dept Psiquiatria, Lab Neurociencias LIM27, Sao Paulo, Brazil

[3] Univ Sao Paulo, Pos Grad Biotecnol, Sao Paulo, Brazil

[4] Fiocruz MS, Escola Nacl Saude Publ, Dept Epidemiol & Metodos Quantitat Saude, Rio De Janeiro, Brazil

[5] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2007年 / 190卷 / 1-2期

关键词：

ninjurin; single nucleotide polymorphism; neuroprotection; leprosy; population;

D O I：

10.1016/j.jneuroim.2007.07.015

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Leprosy is the major cause of non-traumatic neuropathy. Herein, we investigated the role of ninjurin 1, an adhesion molecule involved in nerve regeneration in leprosy. Our results demonstrated that M leprae stimulates in vitro up-regulation of ninjurin mRNA in cultured Schwann and blood cells as well as in vivo mRNA and protein expression in leprosy nerve biopsies. A polymorphism (asp 110ala) was investigated in a casecontrol study (1123 individuals) and no association was found with leprosy per se or with disseminated forms. Nevertheless, ala110 was associated with functional nerve impairment (OR=2.42; p=0.02 for ala/ala) and with lower mRNA levels. Our data suggests that asp110ala could be a valuable genetic marker of nerve damage in leprosy. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：131 / 138

页数：8

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