Quantification of the extraction fraction for gadopentetate across breast cancer capillaries

被引:71
作者
Daldrup, HE
Shames, DM
Husseini, W
Wendland, MF
Okuhata, Y
Brasch, RC
机构
[1] Univ Calif San Francisco, Dept Radiol, San Francisco, CA 94243 USA
[2] Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94243 USA
[3] Univ Munster, Inst Clin Radiol, D-4400 Munster, Germany
关键词
cancer; vasculature; breast; microvessel; permeability; extraction fraction;
D O I
10.1002/mrm.1910400406
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
To quantify the extraction fraction, E, for gadopentetate across tumor capillaries, R3230 adenocarcinomas were implanted in the mammary fat pads of seven rats, The value of E was determined by using a two-compartment tissue model in which the endothelial transfer coefficient, K-PS (ml.min(-1).cc(-1) of tissue), was estimated from the model fitted to changes in R-1 relaxation time (Delta R-1; s(-1)) measured by dynamic three-dimensional spoiled gradient recalled magnetic resonance imaging after injection of 0.1 mmol.kg(-1) of gadopentetate dimeglumine, The plasma flow rate through the tumor capillaries, F-p, (ml.min(-1).g(-1) of tissue), was independently measured with fluorescent microspheres. E could be calculated by the relationship, E = K-PS/F-p. The mean E for gadopentetate in the R3230 tumor was 0.197 +/- 0.118 with a range of 0.123-0.454. The relatively small mean value of E for gadopentetate allows a fair approximation of the permeability surface area product by K-PS in this R3230 tumor model.
引用
收藏
页码:537 / 543
页数:7
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