Synthesis, characterization and DNA-binding properties of a new cobalt(II) complex:: Co(bbt)2Cl2

被引：115

作者：

Jiao, K ^{[1
]}

Wang, QX

Sun, W

Jian, FF

机构：

[1] Qingdao Univ Sci & Technol, Coll Chem & Mol Engn, Qingdao 266042, Peoples R China

[2] Qingdao Univ Sci & Technol, Lab New Mat & Funct Cpds, Qingdao 266042, Peoples R China

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2005年 / 99卷 / 06期

基金：

中国国家自然科学基金;

关键词：

cobalt complex; DNA; voltammetry; spectrophotometry;

D O I：

10.1016/j.jinorgbio.2005.03.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new bis(N-benzyl-benzotriazole)dichloro Co(II) complex (Co(bbt)(2)Cl-2) was synthesized and the structure was characterized by X-ray crystallography, IR spectrum and elemental analysis. The electrochemical characterization of Co(bbt)(2)Cl-2 was measured in detail, and the interaction of this Co(II) complex with fish sperm DNA was studied by electrochemical techniques and ultraviolet-visible (UV-Vis) spectrophotometry. The cyclic voltammetry (CV) showed that Co(bbt)(2)Cl-2 had two reduction peaks and one oxidation peak on gold electrode. It was found that the currents of both the reduction peaks and the oxidation peak decreased significantly in the presence of DNA compared with those in the absence of DNA, which indicated that Co(bbt)(2)Cl-2 could interact with DNA. The binding of DNA with the complex was not only electrostatic binding but also intercalation. (C) 2005 Elsevier Inc. All rights reserved.

引用

页码：1369 / 1375

页数：7

共 32 条

[1]

BARD AJ, 1980, ELECTROCHEMICAL METH

[2] TRIS(PHENANTHROLINE)RUTHENIUM(II) - STEREOSELECTIVITY IN BINDING TO DNA [J].

BARTON, JK ;

DANISHEFSKY, AT ;

GOLDBERG, JM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1984, 106 (07) :2172-2176

[3] TRANSITION-METAL COORDINATION-COMPOUNDS OF A NOVEL ANILINE-BASED PYRAZOLE DERIVATIVE - X-RAY CRYSTAL-STRUCTURES OF [NN-BIS(3,5-DIMETHYLPYRAZOL-1-YLMETHYL)AMINOBENZENE]-DICHLOROCOBALT(II) AND [NN-BIS(3,5-DIMETHYLPYRAZOL-1-YLMETHYL)AMINOBENZENE]-DIBROMOCOPPER(II) [J].

BLONK, HL ;

DRIESSEN, WL ;

REEDIJK, J .

JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 1985, (08) :1699-1705

[4] VOLTAMMETRIC STUDIES OF THE INTERACTION OF METAL-CHELATES WITH DNA .2. TRIS-CHELATED COMPLEXES OF COBALT(III) AND IRON(II) WITH 1,10-PHENANTHROLINE AND 2,2'-BIPYRIDINE [J].

CARTER, MT ;

RODRIGUEZ, M ;

BARD, AJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (24) :8901-8911

[5] RUTHENIUM 1992 [J].

CHAN, S ;

WONG, WT .

COORDINATION CHEMISTRY REVIEWS, 1995, 138 :219-296

[6] Bis(1-acetophenone-1H-benzotriazole-κN3)-dichlorozinc(II) [J].

Jian, FF ;

Xiao, HL ;

Sun, PP .

ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2004, 60 :M38-M39

[7] A STUDY OF THE INTERACTIONS OF SOME POLYPYRIDYLRUTHENIUM(II) COMPLEXES WITH DNA USING FLUORESCENCE SPECTROSCOPY, TOPOISOMERIZATION AND THERMAL-DENATURATION [J].

KELLY, JM ;

TOSSI, AB ;

MCCONNELL, DJ ;

OHUIGIN, C .

NUCLEIC ACIDS RESEARCH, 1985, 13 (17) :6017-6034

[8] GENERAL EXPRESSION OF THE LINEAR POTENTIAL SWEEP VOLTAMMOGRAM IN THE CASE OF DIFFUSIONLESS ELECTROCHEMICAL SYSTEMS [J].

LAVIRON, E .

JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 1979, 101 (01) :19-28

[9] Nickle(II) and cobalt(II) complexes of hydroxyl-substituted triazamacrocyclic ligand as potential antitumor agents [J].

Liang, F ;

Wang, P ;

Zhou, X ;

Li, T ;

Li, ZY ;

Lin, HK ;

Gao, DZ ;

Zheng, CY ;

Wu, CT .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (08) :1901-1904

[10] ELECTROORGANIC PREPARATIONS .25. POLAROGRAPHY AND REDUCTION OF BENZOTRIAZOLE AND RELATED COMPOUNDS [J].

LUND, H ;

KWEE, S .

ACTA CHEMICA SCANDINAVICA, 1968, 22 (09) :2879-&

← 1 2 3 4 →