The preparation of highly substituted pyridazines via a tethered imine-enamine (TIE) procedure

被引：8

作者：

Geyelin, Peter H. ^{[1
]}

Raw, Steven A. ^{[1
]}

Taylor, Richard J. K. ^{[1
]}

机构：

[1] Univ York, Dept Chem, York YO10 5DD, N Yorkshire, England

来源：

ARKIVOC | 2007年

关键词：

1,2,4,5-Tetrazines; pyridazines; inverse electron demand Diels-Alder;

D O I：

10.3998/ark.5550190.0008.b03

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1,2,4,5-Tetrazines can be converted directly into cyclo-annelated pyridazines via an inverse electron demand Diels-Alder procedure incorporating tethered imine-enamine (TIE) methodology. This methodology provides an improved one-pot preparation of such compounds, eliminating the need for either the preformation of the enamine or a separate aromatisation step, and has been applied to 4 tetrazines producing 11 pyridazines.

引用

页码：37 / 45

页数：9

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