Titania nanotubes: A novel platform for drug-eluting coatings for medical implants?

被引:282
作者
Popat, Ketul C.
Eltgroth, Matthew
La Tempa, Thomas J.
Grimes, Craig A.
Desai, Tejal A.
机构
[1] Univ Calif San Francisco, Dept Physiol, Div Bioengn, San Francisco, CA 94143 USA
[2] Colorado State Univ, Dept Mech Engn, Sch Biomed Engn, Ft Collins, CO 80523 USA
[3] Univ Calif San Francisco, Sch Med, San Francisco, CA 94143 USA
[4] Penn State Univ, Dept Elect Engn, University Pk, PA 16802 USA
关键词
biomedicine; drug delivery; nanotubes; titania;
D O I
10.1002/smll.200700412
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Development of novel drug delivery platforms where the size, size distribution, porosity, geometry and surface functionality can be controlled at the nanoscale is the major advancement in nanoscience development. In drug delivery, nanoparticles, quantum dots, and nanotubes have potential applications and serves as nanodelivery platforms. Some nanoscale architectures could be useful for implantable medical devices such as orthopedic implants, vascular stents, and dental implants. The nanotube based localized drug delivery system makes use of Titania and its alloys in implantable devices such as orthopedic and dental implants and serves as an efficient biocompatible material. The nanotubes can be fabricated on any three dimensional nonplanar surfaces making it readily adaptable to the implant technology. The use of titania nanotubes as drug eluting coatings for implantable devices is thereby concluded valid and efficient.
引用
收藏
页码:1878 / 1881
页数:4
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