Background Estimates of the extent of musculoskeletal disorders (MSD) are usually based upon workers' compensation reports, although recent reports indicate that there may be widespread under-reporting of MSD. Methods An estimate of the incidence of ann and hand work-related MSD was made using capture-recapture analysis of the overlap between state workers' compensation reports and physician reports in Connecticut for 1995. The resulting estimate was compared to a population-based survey of MSD. Results There was very small overlap between the two state injury reporting systems: 6.7% of 793 reported workers' compensation cases, or 8% of 661 physician's reports. The estimate for MSD not captured by either system was 13,285 resulting in 14, 686 (95% CI: 9,733-18,453) total reported and non-reported cases. This compares to an estimate of 13, 775 cases (95% CI: 8,800-18,800) based on a phone survey. Conclusions This analysis points to substantial under-reporting of MSD in Connecticut: estimates of unreported cases exceed those officially, reported by a factor of 11:1. The findings have an important bearing on injury prevention programs and policy making. Am. J. Ind. Med. 39:636-642, 2001. (C) 2001 Wiley-Liss, Inc.