Novel tricyclic benzothiazolo[2,3-c]thiadiazine antagonists of the platelet ADP receptor (P2Y12)

被引：23

作者：

Scarborough, RM ^{[1
]}

Laibelman, AM

Clizbe, LA

Fretto, LJ

Conley, PB

Reynolds, EE

Sedlock, DM

Jantzen, HM

机构：

[1] COR Therapeut Inc, Dept Med Chem, S San Francisco, CA 94080 USA

[2] COR Therapeut Inc, Dept Biol, S San Francisco, CA 94080 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 14期

关键词：

D O I：

10.1016/S0960-894X(01)00313-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Novel non-nucleoside tricyclic platelet ADP receptor (P2Y(12)) antagonists hat e been discovered that bind reversibly and with high affinity to the platelet receptor. Condensation of various 2-aminobenzothiazoles with chlorosulfonylacetyl chloride affords these novel tricyclic heterocycles, which are novel and unpredicted products of this reaction. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1805 / 1808

页数：4

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