The role of Y-encoded genes in mammalian spermatogenesis

被引：39

作者：

Burgoyne, PS ^{[1
]}

机构：

[1] Natl Inst Med Res, Lab Dev Genet, London NW7 1AA, England

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 1998年 / 9卷 / 04期

关键词：

azoospermia factor; male infertility; spermatogenesis; Upsilon chromosome;

D O I：

10.1006/scdb.1998.0228

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

As long ago as 1931 Fisher outlined the reasons for the accumulation of male 'benefit genes' (e.g. male fertility factors) on the Y chromosome, but it was over four decades later that a study of men with partial Y chromosome deletions revealed that a factor essential for male fertility was present on the human Y. Today, the Y deletion interval containing this 'Azoospermia Factor' (AZF) has been subdivided into three subintervals associated with different degrees of spermatogenic impairment. Furthermore, three deletion intervals have been identified on the mouse Y that impact on the spermatogenic process. This review examines these deletion intervals in mouse and man and summarises progress towards identifying candidate genes for their respective spermatogenic functions.

引用

页码：423 / 432

页数：10

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