Glucocorticoid upregulation of glutamate dehydrogenase gene expression in vitro in astrocytes

被引：16

作者：

HardinPouzet, H

Giraudon, P

Belin, MF

DidierBazes, M

机构：

[1] INSERM U433, Fac. de Med. A. Carrel, 69372 Lyon Cedex 08, rue G. Paradin

来源：

MOLECULAR BRAIN RESEARCH | 1996年 / 37卷 / 1-2期

关键词：

astrocyte; glucocorticoid; glutamate metabolism; GDH promoter; neuron-glia interactions;

D O I：

10.1016/0169-328X(95)00327-O

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Glutamate, the major excitatory neurotransmitter, is preferentially catabolized in astrocytes by glutamate dehydrogenase (GDH). Treatment of an astrocytic cell line with hydrocortisone (10(-5) M) resulted in increased expression of GDH mRNA. Transfection of the cells with truncated parts of the GDH promoter showed that genomic responsive elements activated by hydrocortisone are localized in the -557/+1 region of the promoter. This control of GDH expression by glucocorticoids may be involved in their protective effect against glutamate excitotoxicity.

引用

页码：324 / 328

页数：5

共 34 条

[1] ASTROCYTIC CELL CLONES DERIVED FROM ESTABLISHED CULTURES OF 8-DAY POSTNATAL MOUSE CEREBELLA [J].