Identification and characterization of a new splicing variant of vascular endothelial growth factor: VEGF183

被引：66

作者：

Lei, JX ^{[1
]}

Jiang, AX ^{[1
]}

Pei, DQ ^{[1
]}

机构：

[1] Univ Minnesota, Dept Pharmacol, Minneapolis, MN 55455 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 1998年 / 1443卷 / 03期

关键词：

splice variant; vascular endothelial growth factor; angiogenesis; neovascularization; gene expression;

D O I：

10.1016/S0167-4781(98)00240-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We report the discovery of a new splicing variant of vascular endothelial growth factor named VEGF183. It is six amino acids shorter than its closest relative, VEGF189, due to the utilization of a conserved alternate splicing donor site within exon 6a. Highly expressed in heart tissue, VEGF183 is detected in transiently transfected COS cells as 28-32-kDa monomers under reduced condition, and 46-kDa dimers under non-reduced condition - the functional unit for all VEGF isoforms. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：400 / 406

页数：7

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