Follicular B helper T cells in antibody responses and autoimmunity

被引：458

作者：

Vinuesa, CG

Tangye, SG

Moser, B

Mackay, CR

机构：

[1] Garvan Inst Med Res, Arthritis & Asthma Res Program, Sydney, NSW 2010, Australia

[2] Australian Natl Univ, John Curtin Sch Med Res, Div Immunol & Genet, Canberra, ACT 2601, Australia

[3] Centenary Inst Canc Med & Cell Biol, Newtown, NSW 2042, Australia

[4] Univ Bern, Inst Cell Biol, CH-3012 Bern, Switzerland

来源：

NATURE REVIEWS IMMUNOLOGY | 2005年 / 5卷 / 11期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/nri1714

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T-cell help for B cells is essential for high-affinity antibody responses and B-cell memory. Recently, the identity of a discrete follicular population of T cells that has a crucial role in this process has become clearer. Similar to primed CD4(+) T cells in the tonsils and memory CD4+ T cells in the peripheral blood, this follicular population of T cells expresses CXC-chemokine receptor 5 (CXCR5). Owing to their distinct homing preferences and helper function, these T cells differ from T helper 1 and T helper 2 cells and have been denoted follicular B helper T cells. Here, we outline the central role of this subset in normal and pathological immune responses.

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页码：853 / 865

页数：13

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