Global burden of respiratory infections due to seasonal influenza in young children: a systematic review and meta-analysis

被引：704

作者：

Nair, Harish ^{[1
,2
]}

Brooks, W. Abdullah ^{[3
]}

Katz, Mark ^{[4
,5
]}

Roca, Anna ^{[6
]}

Berkley, James A. ^{[7
,8
]}

Madhi, Shabir A. ^{[9
,10
,11
]}

Simmerman, James Mark ^{[12
]}

Gordon, Aubree ^{[13
,14
]}

Sato, Masatoki ^{[15
]}

Howie, Stephen ^{[16
]}

Krishnan, Anand ^{[17
]}

Ope, Maurice

Lindblade, Kim A. ^{[18
,20
]}

Carosone-Link, Phyllis ^{[19
]}

Lucero, Marilla

Ochieng, Walter ^{[21
]}

Kamimoto, Laurie ^{[22
]}

Dueger, Erica ^{[23
]}

Bhat, Niranjan ^{[24
]}

Vong, Sirenda

Theodoratou, Evropi

Chittaganpitch, Malinee ^{[25
]}

Chimah, Osaretin ^{[16
,26
]}

Balmaseda, Angel

Buchy, Philippe

Harris, Eva ^{[13
]}

Evans, Valerie

Katayose, Masahiko ^{[27
]}

Gaur, Bharti ^{[17
]}

O'Callaghan-Gordo, Cristina ^{[6
]}

Goswami, Doli ^{[3
]}

Arvelo, Wences ^{[18
]}

Venter, Marietjie ^{[28
,29
]}

Briese, Thomas ^{[30
]}

Tokarz, Rafal ^{[30
]}

Widdowson, Marc-Alain ^{[22
]}

Mounts, Anthony W. ^{[31
]}

Breiman, Robert F. ^{[4
,5
]}

Feikin, Daniel R. ^{[4
,5
]}

Klugman, Keith P. ^{[32
,33
]}

Olsen, Sonja J. ^{[12
]}

Gessner, Bradford D. ^{[34
]}

Wright, Peter F. ^{[35
]}

Rudan, Igor ^{[36
]}

Broor, Shobha

Simoes, Eric A. F. ^{[19
,20
,37
]}

Campbell, Harry

机构：

[1] Univ Edinburgh, Ctr Populat Hlth Sci, Sch Med, Global Hlth Acad, Edinburgh EH8 9AG, Midlothian, Scotland

[2] Publ Hlth Fdn India, New Delhi, India

[3] Int Ctr Diarrhoeal Dis Res, Dhaka 1000, Bangladesh

[4] Kenya Govt Med Res Ctr, Nairobi, Kenya

[5] Ctr Dis Control & Prevent Kenya, Nairobi, Kenya

[6] Univ Barcelona, Ctr Int Hlth Res CRESIB, Hosp Clin, IDIBAPS, Barcelona, Spain

[7] Ctr Geog Med Res Coast, Kilin, Kenya

[8] Univ Oxford, Ctr Clin Vaccinol & Trop Med, Oxford, England

[9] Univ Witwatersrand, Med Res Council, Resp & Meningeal Pathogens Res Unit, ZA-2050 Johannesburg, South Africa

[10] Univ Witwatersrand, Dept Sci & Technol, ZA-2050 Johannesburg, South Africa

[11] Univ Witwatersrand, Natl Res Fdn Vaccine Preventable Dis, ZA-2050 Johannesburg, South Africa

[12] US Ctr Dis Control & Prevent Thailand, Div & Int Emerging Infect Program, MOPH Collaborat, Nonthaburi, Thailand

[13] Univ Calif Berkeley, Div Infect Dis & Vaccinol, Berkeley, CA 94720 USA

[14] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA

[15] Fukushima Med Univ, Dept Paediat, Sch Med, Fukushima, Japan

[16] Med Res Council UK Labs, Banjul, Gambia

[17] All India Inst Med Sci, New Delhi, India

[18] Ctr Dis Control & Prevent, Global Dis Detect Program, Reg Off Cent Amer & Panama, Guatemala City, Guatemala

[19] Univ Colorado, Denver, CO 80202 USA

[20] Childrens Hosp, Denver, CO 80218 USA

[21] Kenya Govt Med Res Ctr, Ctr Virus Res, Nairobi, Kenya

[22] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA

[23] Global Dis Detect & Response Ctr, Naval Med Res Unit 3, Cairo, Egypt

[24] Johns Hopkins Bloomberg Sch Publ Hlth, Ctr Amer Indian Hlth, Baltimore, MD USA

[25] Minist Publ Hlth, Natl Inst Hlth, Nonthaburi, Thailand

[26] Med Ctr, Asaba, Delta State, Nigeria

[27] Soma Gen Hosp, Dept Paediat, Soma, Japan

[28] Natl Inst Communicable Dis, Resp Virus Unit, Natl Inflenza Ctr, Natl Hlth Lab Serv, Johannesburg, South Africa

[29] Univ Pretoria, Resp & Zoonot Virus Programme, Dept Med Virol, ZA-0002 Pretoria, South Africa

[30] Columbia Univ, Ctr Infect & Immun, Mailman Sch Publ Hlth, New York, NY USA

[31] World Hlth Org, Global Influenza Program, Geneva, Switzerland

[32] Emory Univ, Dept Global Hlth, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA

[33] Emory Univ, Div Infect Dis, Sch Med, Atlanta, GA 30322 USA

[34] Agence Med Prevent, Paris, France

[35] Dartmouth Med Sch, Div Infect Dis & Int Hlth, Lebanon, NH USA

[36] Univ Split, Croatian Ctr Global Hlth, Fac Med, Split, Croatia

[37] Univ Padjadjaram, Bandung, Indonesia

来源：

LANCET | 2011年 / 378卷 / 9807期

基金：

比尔及梅琳达.盖茨基金会;

关键词：

COMMUNITY-ACQUIRED PNEUMONIA; HUMAN-IMMUNODEFICIENCY-VIRUS; SYNCYTIAL VIRUS; HUMAN METAPNEUMOVIRUS; TRACT INFECTIONS; VIRAL ETIOLOGY; UNITED-STATES; STREPTOCOCCUS-PNEUMONIAE; PNEUMOCOCCAL PNEUMONIA; CHILDHOOD PNEUMONIA;

D O I：

10.1016/S0140-6736(11)61051-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background The global burden of disease attributable to seasonal influenza virus in children is unknown. We aimed to estimate the global incidence of and mortality from lower respiratory infections associated with influenza in children younger than 5 years. Methods We estimated the incidence of influenza episodes, influenza-associated acute lower respiratory infections (ALRI), and influenza-associated severe ALRI in children younger than 5 years, stratified by age, with data from a systematic review of studies published between Jan 1, 1995, and Oct 31, 2010, and 16 unpublished population-based studies. We applied these incidence estimates to global population estimates for 2008 to calculate estimates for that year. We estimated possible bounds for influenza-associated ALRI mortality by combining incidence estimates with case fatality ratios from hospital-based reports and identifying studies with population-based data for influenza seasonality and monthly ALRI mortality. Findings We identified 43 suitable studies, with data for around 8 million children. We estimated that, in 2008, 90 million (95% CI 49-162 million) new cases of influenza (data from nine studies), 20 million (13-32 million) cases of influenza-associated ALRI (13% of all cases of paediatric ALRI; data from six studies), and 1 million (1-2 million) cases of influenza-associated severe ALRI (7% of cases of all severe paediatric ALRI; data from 39 studies) occurred worldwide in children younger than 5 years. We estimated there were 28 000-111 500 deaths in children younger than 5 years attributable to influenza-associated ALRI in 2008, with 99% of these deaths occurring in developing countries. Incidence and mortality varied substantially from year to year in any one setting. Interpretation Influenza is a common pathogen identified in children with ALRI and results in a substantial burden on health services worldwide. Sufficient data to precisely estimate the role of influenza in childhood mortality from ALRI are not available.

引用

页码：1917 / 1930

页数：14

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