The Cell Biology of Synaptic Plasticity

被引：433

作者：

Ho, Victoria M. ^{[2
]}

Lee, Ji-Ann ^{[1
]}

Martin, Kelsey C. ^{[1
,3
,4
]}

机构：

[1] Univ Calif Los Angeles, Dept Biol Chem, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Interdept Program Neurosci, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA

[4] Univ Calif Los Angeles, Brain Res Inst, Los Angeles, CA 90095 USA

来源：

SCIENCE | 2011年 / 334卷 / 6056期

关键词：

LONG-TERM POTENTIATION; DENDRITIC PROTEIN-SYNTHESIS; II MUTANT MICE; AMPA RECEPTORS; TRANSLATIONAL CONTROL; MESSENGER-RNA; CYTOPLASMIC POLYADENYLATION; DEPENDENT TRANSLATION; RECYCLING ENDOSOMES; HIPPOCAMPAL-NEURONS;

D O I：

10.1126/science.1209236

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Synaptic plasticity is the experience-dependent change in connectivity between neurons that is believed to underlie learning and memory. Here, we discuss the cellular and molecular processes that are altered when a neuron responds to external stimuli, and how these alterations lead to an increase or decrease in synaptic connectivity. Modification of synaptic components and changes in gene expression are necessary for many forms of plasticity. We focus on excitatory neurons in the mammalian hippocampus, one of the best-studied model systems of learning-related plasticity.

引用

页码：623 / 628

页数：6

共 63 条

[1] Hippocampal Short- and Long-Term Plasticity Are Not Modulated by Astrocyte Ca2+ Signaling [J].

Agulhon, Cendra ;

Fiacco, Todd A. ;

McCarthy, Ken D. .

SCIENCE, 2010, 327 (5970) :1250-1254

[2] Changes in AMPA receptor currents following LTP induction on rat CA1 pyramidal neurones [J].

Andrásfalvy, BK ;

Magee, JC .

JOURNAL OF PHYSIOLOGY-LONDON, 2004, 559 (02) :543-554

[3] A Coordinated Local Translational Control Point at the Synapse Involving Relief from Silencing and MOV10 Degradation [J].

Banerjee, Sourav ;

Neveu, Pierre ;

Kosik, Kenneth S. .

NEURON, 2009, 64 (06) :871-884

[4] Activity-dependent dynamics and sequestration of proteasomes in dendritic spines [J].

Bingol, Baris ;

Schuman, Erin M. .

NATURE, 2006, 441 (7097) :1144-1148

[5] Synaptic incorporation of AMPA receptors during LTP is controlled by a PKC phosphorylation site on GluR1 [J].

Boehm, Jannic ;

Kang, Myoung-Goo ;

Johnson, Richard C. ;

Esteban, Jose ;

Huganir, Richard L. ;

Malinow, Roberto .

NEURON, 2006, 51 (02) :213-225

[6] PSA-NCAM in mammalian structural plasticity and neurogenesis [J].

Bonfanti, Luca .

PROGRESS IN NEUROBIOLOGY, 2006, 80 (03) :129-164

[7] Do thin spines learn to be mushroom spines that remember? [J].

Bourne, Jennifer ;

Harris, Kristen M. .

CURRENT OPINION IN NEUROBIOLOGY, 2007, 17 (03) :381-386

[8] CaMKII "Autonomy" Is Required for Initiating But Not for Maintaining Neuronal Long-Term Information Storage [J].

Buard, Isabelle ;

Coultrap, Steven J. ;

Freund, Ronald K. ;

Lee, Yong-Seok ;

Dell'Acqua, Mark L. ;

Silva, Alcino J. ;

Bayer, K. Ulrich .

JOURNAL OF NEUROSCIENCE, 2010, 30 (24) :8214-8220

[9] RIM1α is required for presynaptic long-term potentiation [J].

Castillo, PE ;

Schoch, S ;

Schmitz, F ;

Südhof, TC ;

Malenka, RC .

NATURE, 2002, 415 (6869) :327-330

[10] The synapsins: Key actors of synapse function and plasticity [J].

Cesca, F. ;

Baldelli, P. ;

Valtorta, F. ;

Benfenati, F. .

PROGRESS IN NEUROBIOLOGY, 2010, 91 (04) :313-348

← 1 2 3 4 5 6 7 →