Osteoprotegerin ligand: A common link between osteoclastogenesis, lymph node formation and lymphocyte development

被引：107

作者：

Kong, YY

Boyle, WJ

Penninger, JM

机构：

[1] Amgen Inst, Ontario Canc Inst, Toronto, ON M5G 2C1, Canada

[2] Univ Toronto, Dept Med Biophys, Toronto, ON, Canada

[3] Univ Toronto, Dept Immunol, Toronto, ON, Canada

[4] Amgen Inc, Dept Cell Biol, Thousand Oaks, CA 91320 USA

来源：

IMMUNOLOGY AND CELL BIOLOGY | 1999年 / 77卷 / 02期

关键词：

lymph node genesis; lymphocyte development; osteoclastogenesis; osteoprotegerin ligand;

D O I：

10.1046/j.1440-1711.1999.00815.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The TNF-family molecule osteoprotegerin ligand (OPGL; also known as TRANCE, RANKL or ODF) has been identified as the osteoclast differentiation factor and a regulator of T cell-dendritic cell interactions in the immune system. Surprisingly, the same molecule was identified as a crucial factor in early lymphocyte: development and lymph node organogenesis. We will discuss the role of OPGL in bone remodelling and the immune system.

引用

收藏

页码：188 / 193

页数：6

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