Changes in cancer worry associated with participation in ovarian cancer screening

被引:41
作者
Andersen, M. Robyn
Drescher, Chades W.
Zheng, Yingye
Bowen, Deborah J.
Wilson, Susan
机构
[1] Fred Hutchinson Canc Res Ctr, Translat & Outcomes Res Grp, Seattle, WA 98109 USA
[2] Univ Washington, Sch Publ Hlth, Seattle, WA 98195 USA
[3] Marsha Rivkin Ctr Ovarian Canc Res, Seattle, WA USA
[4] Seattle Ultrasound Associates, Seattle, WA USA
关键词
ovarian cancer; screening; worry about cancer risk; randomized controlled trial; false-positives;
D O I
10.1002/pon.1151
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
While ovarian cancer is rare and screening is not recommended for most women, it is being studied as a way to reduce ovarian cancer mortality. As effective strategies for screening emerge it will be important to understand the quality of life (QOL) effects of participation in ovarian cancer screening. In this study, we examined the effects of participation in an ovarian cancer screening program on worry about cancer risk and QOL. A randomized controlled clinical trial (n = 592) was conducted. Women without a family history suggestive of a BRCA1/2 mutation were randomly assigned to screening and risk counseling, separately and in combination. Results were compared to women randomized to usual care alone. Levels of cancer worry fell for all study groups and QOL was unaffected; no statistically significant differences were found between groups. Increased levels of worry about ovarian cancer at 2-year follow-up were found among participants in screening receiving abnormal test results. For those who receive abnormal results, screening may have long-term effects and increase worry about cancer risk. Further research will be required to examine the possibility that screening reduces worry when women receive only normal, presumably reassuring, results. Copyright (c) 2007 John Wiley & Sons, Ltd.
引用
收藏
页码:814 / 820
页数:7
相关论文
共 44 条
  • [1] Examining the cost-effectiveness of cancer screening promotion
    Andersen, MR
    Urban, N
    Ramsey, S
    Briss, PA
    [J]. CANCER, 2004, 101 (05) : 1229 - 1238
  • [2] Andersen MR, 2003, CANCER EPIDEM BIOMAR, V12, P314
  • [3] Worry about ovarian cancer risk and use of ovarian cancer screening by women at risk for ovarian cancer
    Andersen, MR
    Peacock, S
    Nelson, J
    Wilson, S
    McIntosh, M
    Drescher, C
    Urban, N
    [J]. GYNECOLOGIC ONCOLOGY, 2002, 85 (01) : 3 - 8
  • [4] ANDERSEN MR, 2002, CLIN J WOMENS HLTH, V2, P5, DOI DOI 10.1053/CJWH.2002.31881
  • [5] Social implications of security and crime prevention
    Andrews, CJ
    [J]. IEEE TECHNOLOGY AND SOCIETY MAGAZINE, 2004, 23 (03) : 6 - 6
  • [6] [Anonymous], 2005, Cancer facts and figures
  • [7] False-positive findings in mammography screening induces shortterm distress - breast cancer-specific concern prevails longer
    Aro, AR
    Absetz, SP
    van Elderen, TM
    van der Ploeg, E
    van der Kamp, LJT
    [J]. EUROPEAN JOURNAL OF CANCER, 2000, 36 (09) : 1089 - 1097
  • [8] Bakker D A, 1998, Oncol Nurs Forum, V25, P115
  • [9] Bast RC, 1995, J CELL BIOCHEM, P219
  • [10] Bowen D, 1999, CANCER EPIDEM BIOMAR, V8, P581