The regulation of immunoglobulin E class-switch recombination

被引：344

作者：

Geha, RS ^{[1
]}

Jabara, HH

Brodeur, SR

机构：

[1] Harvard Univ, Sch Med, Div Immunol, Childrens Hosp, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2003年 / 3卷 / 09期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nri1181

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immunoglobulin E (IgE) isotype antibodies are associated with atopic disease, namely allergic rhinitis, asthma and atopic dermatitis, but are also involved in host immune defence mechanisms against parasitic infection. The commitment of a B cell to isotype class switch to an IgE-producing cell is a tightly regulated process, and our understanding of the regulation of IgE-antibody production is central to the prevention and treatment of atopic disease. Both those that are presently in use and potential future therapies to prevent IgE-mediated disease take advantage of our existing knowledge of the specific mechanisms that are required for IgE class switching.

引用

页码：721 / 732

页数：12

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