Concise Review: Mesenchymal Stem Cell Treatment of the Complications of Diabetes Mellitus

被引：305

作者：

Volarevic, Vladislav ^{[1
]}

Arsenijevic, Nebojsa ^{[1
]}

Lukic, Miodrag L. ^{[1
,2
]}

Stojkovic, Miodrag ^{[1
,3
]}

机构：

[1] Univ Kragujevac, Ctr Mol Med, Fac Med, Kragujevac 34000, Serbia

[2] UAE Univ, Fac Med & Hlth Sci, Dept Microbiol & Immunol, Al Ain, U Arab Emirates

[3] Spebo Med, Leskovac 16000, Serbia

来源：

STEM CELLS | 2011年 / 29卷 / 01期

关键词：

Mesenchymal stem cell; Cardiomyopathy; Nephropathy; Neuropathy; Wound; Diabetes mellitus; INSULIN-PRODUCING CELLS; MULTIPOTENT STROMAL CELLS; MURINE BONE-MARROW; IN-VITRO; GROWTH-FACTOR; HEART-RATE; RATS; MICE; DIFFERENTIATION; STREPTOZOTOCIN;

D O I：

10.1002/stem.556

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

Mesenchymal stem cells (MSCs) are multipotent, self-renewing cells that can be found in almost all postnatal organs and tissues. The main functional characteristics of MSCs are their immunomodulatory ability, capacity for self-renewal, and differentiation into mesodermal tissues. The ability of MSCs to differentiate into several cell types, including muscle, brain, vascular, skin, cartilage, and bone cells, makes them attractive as therapeutic agents for a number of diseases including complications of diabetes mellitus. We review here the potential of MSCs as new therapeutic agents in the treatment of diabetic cardiomyopathy, diabetic nephropathy, diabetic polyneuropathy, diabetic retinopathy, and diabetic wounds. Also, in this review we discuss the current limitations for MSCs therapy in humans. STEM CELLS 2011;29:5-10

引用

页码：5 / 10

页数：6

共 46 条

[1]

Immunomodulation by mesenchymal stem cells - A potential therapeutic strategy for type 1 diabetes [J].