Radical cyclizations as key step for the stereoselective synthesis of Bi- and tricyclic sesquiterpene Lactones

被引：22

作者：

Jezek, E ^{[1
]}

Schall, A ^{[1
]}

Kreitmeier, P ^{[1
]}

Reiser, O ^{[1
]}

机构：

[1] Univ Regensburg, Inst Organ Chem, D-93053 Regensburg, Germany

来源：

SYNLETT | 2005年 / 06期

关键词：

radical reactions; radicals; natural products; cyclizations; lactones;

D O I：

10.1055/s-2005-864827

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A strategy towards the stereoselective synthesis of bi-and tricyclic sesquiterpene lactones is reported. As key step radical cyclizations of appropriately functionalized trans-4,5-disubstituted gamma-butyrolactones, which are readily available from methyl 2-furoate, were carried out to give rise to 5,6-, 5,7- and 5,7,5-ring systems in diastereo- and enantiomerically pure form.

引用

页码：915 / 918

页数：4

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