Classification of primary progressive aphasia and its variants

被引：3455

作者：

Gorno-Tempini, M. L. ^{[1
,2
]}

Hillis, A. E. ^{[3
]}

Weintraub, S. ^{[4
]}

Kertesz, A. ^{[5
]}

Mendez, M. ^{[6
]}

Cappa, S. F. ^{[7
]}

Ogar, J. M. ^{[1
]}

Rohrer, J. D. ^{[8
]}

Black, S. ^{[9
]}

Boeve, B. F. ^{[10
]}

Manes, F. ^{[11
]}

Dronkers, N. F. ^{[12
,13
]}

Vandenberghe, R. ^{[14
]}

Rascovsky, K. ^{[1
]}

Patterson, K. ^{[15
]}

Miller, B. L. ^{[1
]}

Knopman, D. S. ^{[10
]}

Hodges, J. R. ^{[16
]}

Mesulam, M. M. ^{[4
]}

Grossman, M. ^{[17
]}

机构：

[1] Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA

[2] Univ Trent, Ctr Mind Brain Sci, Trento, Italy

[3] Johns Hopkins Univ, Dept Neurol, Baltimore, MD 21218 USA

[4] Northwestern Univ, Dept Neurol, Chicago, IL 60611 USA

[5] Univ Western Ontario, London, ON, Canada

[6] Univ Calif Los Angeles, Dept Neurol, Los Angeles, CA 90024 USA

[7] Univ Vita Salute San Raffaele, Milan, Italy

[8] UCL, Inst Neurol, Dementia Res Ctr, London, England

[9] Univ Toronto, Dept Med Neurol, Sunnybrook Hlth Sci Ctr, Toronto, ON, Canada

[10] Mayo Clin, Dept Neurol, Rochester, MN USA

[11] Inst Cognit Neurol, Buenos Aires, DF, Argentina

[12] VA No Calif Hlth Care Syst, Davis, CA USA

[13] Univ Calif Davis, Davis, CA 95616 USA

[14] Univ Leuven, Dept Neurol, Louvain, Belgium

[15] Univ Cambridge, Dept Clin Neurosci, Cambridge, England

[16] Univ New S Wales, Sydney, NSW 2052, Australia

[17] Univ Penn, Dept Neurol, Philadelphia, PA 19104 USA

来源：

NEUROLOGY | 2011年 / 76卷 / 11期

基金：

澳大利亚研究理事会; 英国惠康基金;

关键词：

FRONTOTEMPORAL LOBAR DEGENERATION; VOXEL-BASED MORPHOMETRY; SEMANTIC DEMENTIA; NONFLUENT APHASIA; ALZHEIMERS-DISEASE; GENE-MUTATIONS; ATROPHY; PATTERNS; LANGUAGE; SPEECH;

D O I：

10.1212/WNL.0b013e31821103e6

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This article provides a classification of primary progressive aphasia (PPA) and its 3 main variants to improve the uniformity of case reporting and the reliability of research results. Criteria for the 3 variants of PPA-nonfluent/agrammatic, semantic, and logopenic-were developed by an international group of PPA investigators who convened on 3 occasions to operationalize earlier published clinical descriptions for PPA subtypes. Patients are first diagnosed with PPA and are then divided into clinical variants based on specific speech and language features characteristic of each subtype. Classification can then be further specified as "imaging-supported" if the expected pattern of atrophy is found and "with definite pathology" if pathologic or genetic data are available. The working recommendations are presented in lists of features, and suggested assessment tasks are also provided. These recommendations have been widely agreed upon by a large group of experts and should be used to ensure consistency of PPA classification in future studies. Future collaborations will collect prospective data to identify relationships between each of these syndromes and specific biomarkers for a more detailed understanding of clinicopathologic correlations. Neurology (R) 2011;76:1006-1014

引用

页码：1006 / 1014

页数：9

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