Metabolic acidosis and vascular calcification: Using blueprints from bone to map a new venue for vascular research

被引：6

作者：

Al-Aly, Z. ^{[1
,2
,3
]}

机构：

[1] St Louis Univ Hosp, Div Nephrol, St Louis, MO 63110 USA

[2] St Louis Vet Affairs Med Ctr, Div Nephrol, St Louis, MO USA

[3] St Louis Vet Affairs Clin Res & Epidemiol Workgrp, St Louis, MO USA

来源：

KIDNEY INTERNATIONAL | 2008年 / 73卷 / 04期

关键词：

D O I：

10.1038/sj.ki.5002738

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Vascular calcification is an important problem in patients with chronic kidney disease. The pathobiology of vascular calcification is complex and is intricately related to bone remodeling. Mendoza et al. report that experimental metabolic acidosis prevents calcitriol-induced vascular calcification in uremic animals. To fully understand the effect of acidosis on the vasculature, a comprehensive and integrated approach that simultaneously examines the effect of metabolic acidosis on bone and vasculature is needed.

引用

收藏

页码：377 / 379

页数：3

相关论文

共 14 条

[1]

Al-Aly Ziyad, 2007, Cardiovascular & Hematological Disorders - Drug Targets, V7, P1

[2] Radiographic measure of aorta calcification is a site-specific predictor of bone loss and fracture risk at the hip [J].

Bagger, Y. Z. ;

Tanko, L. B. ;

Alexandersen, P. ;

Qin, G. ;

Christiansen, C. .

JOURNAL OF INTERNAL MEDICINE, 2006, 259 (06) :598-605

[3] Renal bone disease in 76 patients with varying degrees of predialysis chronic renal failure: A cross-sectional study [J].

Coen, G ;

Mazzaferro, S ;

Ballanti, P ;

Sardella, D ;

Chicca, S ;

Manni, M ;

Bonucci, E .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 1996, 11 (05) :813-819

[4]

COEN G, 1995, MINER ELECTROL METAB, V21, P375

[5] Chronic metabolic acidosis alters osteoblast differentiation from human mesenchymal stem cells [J].

Disthabanchong, S. ;

Radinahamed, P. ;

Stitchantrakul, W. ;

Hongeng, S. ;

Rajatanavin, R. .

KIDNEY INTERNATIONAL, 2007, 71 (03) :201-209

[6] Progression of aortic calcification is associated with metacarpal bone loss during menopause - A population-based longitudinal study [J].

Hak, AE ;

Pols, HAP ;

van Hemert, AM ;

Hofman, A ;

Witteman, JCM .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2000, 20 (08) :1926-1931

[7] OPTIMAL CORRECTION OF ACIDOSIS CHANGES PROGRESSION OF DIALYSIS OSTEODYSTROPHY [J].

LEFEBVRE, A ;

DEVERNEJOUL, MC ;

GUERIS, J ;

GOLDFARB, B ;

GRAULET, AM ;

MORIEUX, C .

KIDNEY INTERNATIONAL, 1989, 36 (06) :1112-1118

[8] Arterial calcifications and bone histomorphometry in end-stage renal disease [J].

London, GM ;

Marty, C ;

Marchais, SJ ;

Guerin, AP ;

Metivier, F ;

De Vernejoul, MC .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2004, 15 (07) :1943-1951

[9] Metabolic acidosis inhibits soft tissue calcification in uremic rats [J].

Mendoza, F. J. ;

Lopez, I. ;

De Oca, A. Montes ;

Perez, J. ;

Rodriguez, M. ;

Aguilera-Tejero, E. .

KIDNEY INTERNATIONAL, 2008, 73 (04) :407-414

[10] Bisphosphonates prevent experimental vascular calcification: Treat the bone to cure the vessels? [J].

Persy, V. ;

De Broe, M. ;

Ketteler, M. .

KIDNEY INTERNATIONAL, 2006, 70 (09) :1537-1538