Effects of metrifonate on cognitive decline in Alzheimer disease: A double-blind, placebo-controlled, 6-month study

被引：36

作者：

Becker, RE ^{[1
]}

Colliver, JA ^{[1
]}

Markwell, SJ ^{[1
]}

Moriearty, PL ^{[1
]}

Unni, LK ^{[1
]}

Vicari, S ^{[1
]}

机构：

[1] So Illinois Univ, Sch Med, Dept Psychiat, Springfield, IL USA

来源：

ALZHEIMER DISEASE & ASSOCIATED DISORDERS | 1998年 / 12卷 / 01期

关键词：

Alzheimer disease; acetylcholinesterase inhibitors; cognitive decline; memory; metrifonate; dichlorvos;

D O I：

10.1097/00002093-199803000-00009

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Forty-seven patients with probable Alzheimer disease (AD) completed a 6 month double-blind study to compare metrifonate with placebo. The Alzheimer Disease Assessment Scale cognitive subscale score of the metrifonate group treated to a 50-70% inhibition of red blood cell acetylcholinesterase activity differed significantly from the placebo group score by 1.8 points (p < 0.03) due to a deterioration in cognitive performance in the placebo group (p < 0.01). Statistically significant deterioration also occurred in the Mini-Mental State Examination scores (p < 0.01) in the placebo-treated group. Adverse effects were uncommon and did not require adjustment of the dose of metrifonate or discontinuation of treatment. These findings extend our previous report of a favorable effect of metrifonate on cognitive symptoms in AD by showing clinical, not only statistical, significance.

引用

页码：54 / 57

页数：4

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