The role of insulin and IGF-1 signaling in longevity

被引：161

作者：

Katic, M

Kahn, CR

机构：

[1] Harvard Univ, Sch Med, Joslin Diabet Ctr, Boston, MA 02215 USA

[2] Harvard Univ, Sch Med, Dept Med, Boston, MA 02215 USA

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2005年 / 62卷 / 03期

关键词：

aging; lifespan; genetic instability; telomerase; oxidative stress; superoxide dismutase; oxidants; antioxidants; reactive oxygen species; gluthatione; thioredoxin metabolism; calorie restriction; insulin; IGF-1; growth hormone; signaling; Sir; FOXO; p66; klotho; animal models; S.cerevisiae; C; elegans; D; melanogaster; mouse; knockout; human; syndrome; Ames Dwarf; Snell Dwarf; FIRKO;

D O I：

10.1007/s00018-004-4297-y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

There are many theories of aging and parameters that influence lifespan, including genetic instability, telomerase activity and oxidative stress. The role of caloric restriction, metabolism and insulin and insulin-like growth factor-1 signaling in the process of aging is especially well conserved throughout evolution. These latter factors interact with each other, the former factors and histone deacetylases of the SIR family in a complex interaction to influence lifespan.

引用

收藏

页码：320 / 343

页数：24

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