Effect of chemotherapy with 5-fluorouracil on intestinal permeability and absorption in patients with advanced colorectal cancer

被引:61
作者
Daniele, B
Secondulfo, M
De Vivo, R
Pignata, S
De Magistris, L
Delrio, P
Palaia, R
Barletta, E
Tambaro, R
Carratù, R
机构
[1] Natl Canc Inst, Div Med Oncol, I-80131 Naples, Italy
[2] Natl Canc Inst, Div Surg Oncol, I-80131 Naples, Italy
[3] Second Univ Naples, Gastroenterol Unit, Naples, Italy
关键词
5-fluorouracil; intestinal permeability; intestinal absorption; colorectal cancer;
D O I
10.1097/00004836-200103000-00010
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
5-Fluorouracil (5-FU), in association with leucovorin (LV), is the most used chemotherapy agent in the treatment of colorectal cancer. Response rate, as well as side-effect incidence, increases with the dose intensity of regimens that are used. The most common dose-limiting toxicity for 5-FU/LV modulation is diarrhea. To as sess the modification of small intestinal function, we investigated the changes in intestinal permeability (IP) and intestinal absorption (IA) in 41 chemo-naive patients (21 men and 22 women; mean age, 61 +/- 9 years) with advanced colorectal cancer after treatment with the association of folinic acid and 5-FU. After chemotherapy administration, we found a marked increase in LP and a reduction in IA, measured as cellobiose-mannitol (CE-MA) ratio (p < 0.0001) and D-xylose absorption (p = 0.0001), respectively. Patients who experienced diarrhea have an increase in CE-MA ratio and a reduction in D-xylose absorption values, both statistically significant. Cellobiose-mannitol ratio and D-xylose absorption tests can be used fur the assessment of toxic effect of 5-FU on mature intestinal epithelium and also for evaluating the role of cytoprotective agents.
引用
收藏
页码:228 / 230
页数:3
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