Agmatine uptake by cultured hamster kidney cells

被引：13

作者：

del Valle, AE ^{[1
]}

Paz, JC ^{[1
]}

Sánchez-Jiménez, F ^{[1
]}

Medina, MA ^{[1
]}

机构：

[1] Univ Malaga, Fac Ciencias, Dept Bioquim & Biol Mol, E-29071 Malaga, Spain

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2001年 / 280卷 / 01期

关键词：

agmatine; uptake; kidney; polyamines; DFMO;

D O I：

10.1006/bbrc.2000.4101

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Agmatine, the product of arginine decarboxylation, has been recently found in a wide variety of animal tissues. In spite of the emergent interest on agmatine in animals, the mechanism of agmatine uptake in mammalian cells has been scarcely studied. An analysis of radiolabeled agmatine uptake was carried out by using a classical, kinetic approach with BHK-21 hamster kidney cells in culture. A high affinity, temperature- and energy-dependent agmatine transport system in BHK-21 kidney cells is here kinetically characterized which seems to be a "general" transporter shared by di- and triamines and different to a highly specific carrier for the tetraamine spermine. (C) 2001 Academic Press.

引用

页码：307 / 311

页数：5

共 34 条

[1]

BRACHET P, 1992, BIOCHEM INT, V27, P465

[2]

BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3

[3] Inhibition of mammalian nitric oxide synthases by agmatine, an endogenous polyamine formed by decarboxylation of arginine [J].

Galea, E ;

Regunathan, S ;

Eliopoulos, V ;

Feinstein, DL ;

Reis, DJ .

BIOCHEMICAL JOURNAL, 1996, 316 :247-249

[4]

Li G, 1995, Ann N Y Acad Sci, V763, P325, DOI 10.1111/j.1749-6632.1995.tb32418.x

[5]

LI S, 1994, SCIENCE, V263, P966

[6] Agmatine, a bioactive metabolite of arginine - Production, degradation, and functional effects in the kidney of the rat [J].

Lortie, MJ ;

Novotny, WF ;

Peterson, OW ;

Vallon, V ;

Malvey, K ;

Mendonca, M ;

Satriano, J ;

Insel, P ;

Thomson, SC ;

Blantz, RC .

JOURNAL OF CLINICAL INVESTIGATION, 1996, 97 (02) :413-420

[7] DIAMINES INTERFERE WITH THE TRANSPORT OF L-ORNITHINE IN EHRLICH-CELL PLASMA-MEMBRANE VESICLES [J].

MEDINA, MA ;

URDIALES, JL ;

DECASTRO, IN ;

SANCHEZJIMENEZ, F .

BIOCHEMICAL JOURNAL, 1991, 280 :825-827

[8] Imidazoline recognition sites and stomach function [J].

Molderings, GJ ;

Burian, M ;

Menzel, S ;

Donecker, K ;

Homann, J ;

Nilius, M ;

Göthert, M .

IMIDAZOLINE RECEPTORS AND THEIR ENDOGENOUS LIGANDS: CURRENT CONCEPTS AND THERAPEUTIC POTENTIAL, 1999, 881 :332-343

[9] UPTAKE OF POLYAMINES BY HUMAN ENDOTHELIAL-CELLS - CHARACTERIZATION AND LACK OF EFFECT OF AGONISTS OF ENDOTHELIAL FUNCTION [J].

MORGAN, DML .

BIOCHEMICAL JOURNAL, 1992, 286 :413-417

[10] PARTIAL CLONING AND CHARACTERIZATION OF AN ARGININE DECARBOXYLASE IN THE KIDNEY [J].

MORRISSEY, J ;

MCCRACKEN, R ;

ISHIDOYA, S ;

KLAHR, S .

KIDNEY INTERNATIONAL, 1995, 47 (05) :1458-1461

← 1 2 3 4 →