Tumor microenvironment: The culprit for ovarian cancer metastasis?

被引：179

作者：

Luo, Zhongyue ^{[1
,2
]}

Wang, Qiu ^{[3
]}

Lau, Wayne Bond ^{[4
]}

Lau, Bonnie ^{[5
]}

Xu, Lian ^{[6
]}

Zhao, Linjie ^{[1
,2
]}

Yang, Huiliang ^{[7
]}

Feng, Min ^{[6
]}

Xuan, Yu ^{[1
,2
]}

Yang, Yanfei ^{[1
,2
]}

Lei, Lingzi ^{[1
,2
]}

Wang, Chenlu ^{[8
]}

Yi, Tao ^{[1
,2
]}

Zhao, Xia ^{[1
,2
]}

Wei, Yuquan ^{[1
,2
]}

Zhou, Shengtao ^{[1
,2
]}

机构：

[1] Sichuan Univ, West China Hosp 2, Key Lab Obstet & Gynecol & Pediat Dis & Birth Def, Dept Obstet & Gynecol,Minist Educ, Chengdu 610041, Peoples R China

[2] Sichuan Univ, West China Hosp, Collaborat Innovat Ctr, State Key Lab Biotherapy, Chengdu 610041, Peoples R China

[3] Sichuan Univ, West China Hosp 2, Dept Pediat, Chengdu 610041, Peoples R China

[4] Thomas Jefferson Univ Hosp, Dept Emergency Med, Philadelphia, PA 19107 USA

[5] Stanford Univ, Kaiser Santa Clara Med Ctr, Dept Surg, Emergency Med, Stanford, CA 94305 USA

[6] Sichuan Univ, West China Hosp 2, Dept Pathol, Chengdu 610041, Peoples R China

[7] Sichuan Univ, West China Hosp, Dept Orthoped, Chengdu 610041, Peoples R China

[8] Sichuan Univ, Coll Life Sci, Chengdu 610041, Peoples R China

来源：

CANCER LETTERS | 2016年 / 377卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Tumor microenvironment; Ovarian cancer metastasis; Stromal cells; Extracellular matrix component; Exosomes; ENDOTHELIAL GROWTH-FACTOR; MESENCHYMAL STEM-CELLS; UROKINASE PLASMINOGEN-ACTIVATOR; HEPARAN-SULFATE PROTEOGLYCANS; REGULATORY T-CELLS; CATHEPSIN-D; M2-POLARIZED MACROPHAGES; INDEPENDENT PREDICTOR; EXTRACELLULAR-MATRIX; CLINICAL-RELEVANCE;

D O I：

10.1016/j.canlet.2016.04.038

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Despite chemotherapy and surgical debulking options, ovarian cancer recurs and disseminates frequently, with poor prognosis. However, the molecular mechanisms underlying ovarian cancer metastasis still remain unelucidated. The tumor microenvironment, consisting of stromal cells (including fibroblasts, macrophages, regulatory T cells, myeloid-derived suppressor cells, endothelial cells, pericytes and platelets), the extracellular matrix component (EMC) (including inflammatory cytokines, chemokines, matrix metalloproteinases, integrins, and other secreted molecules) and exosomes (small extracellular vesicles loaded with molecules), establishes an autocrine paracrine communication circuit that reinforces invasion and cancer cell metastasis via reciprocal signaling. Recent evidences have unraveled the significant contribution of tumor microenvironment to ovarian cancer metastasis. In this review, we provide a comprehensive landscape of the reciprocity between tumor stroma and ovarian cancer cells upon metastasis, aiming to offer novel clues on the development of novel diagnostic biomarkers and therapeutic targets for ovarian cancer in future clinical practice. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

引用

页码：174 / 182

页数：9

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