A trial of oral corticosteroids for persistent systemic and airway inflammation in severe asthma

被引：20

作者：

Oishi, Keiji ^{[1
,2
]}

Hirano, Tsunahiko ^{[1
]}

Suetake, Ryo ^{[1
]}

Ohata, Syuichiro ^{[1
]}

Yamaji, Yoshikazu ^{[1
]}

Ito, Kosuke ^{[1
]}

Edakuni, Nobutaka ^{[1
]}

Matsunaga, Kazuto ^{[1
]}

机构：

[1] Yamaguchi Univ, Grad Sch Med, Dept Resp Med & Infect Dis, 1-1-1 Minami Kogushi, Ube, Yamaguchi 7558505, Japan

[2] Yamaguchi Univ, Grad Sch Med, Dept Med & Clin Sci, Div Cardiol, Ube, Yamaguchi, Japan

来源：

IMMUNITY INFLAMMATION AND DISEASE | 2017年 / 5卷 / 03期

关键词：

Asthma; blood eosinophils; exhaled nitric oxide; EXHALED NITRIC-OXIDE; ELEVATION; DISEASE;

D O I：

10.1002/iid3.166

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

IntroductionThe fraction of exhaled nitric oxide (FeNO) and blood eosinophils, markers of local and systemic eosinophilic inflammation, respectively, are increased in asthmatic patients. Little is known concerning the relationship between the FeNO levels and blood eosinophils in asthmatics. MethodsTwenty severe asthmatics with persistent FeNO elevation (40ppb) and blood eosinophilia (3%) despite maintenance therapy including high-daily-dose inhaled corticosteroids were analyzed. We investigated the response of FeNO and blood eosinophils to systemic corticosteroids treatment and the change in Asthma Control Questionnaire (ACQ) according to differences in the response of FeNO and blood eosinophils to steroid. ResultsThe changes in blood eosinophils were not correlated with the changes in FeNO levels by systemic steroid treatment (r=0.37, P=0.11). 50% of the subjects showed both 20% reductions in FeNO levels and blood eosinophils. There were significant differences in the ACQ score between the steroid response group and poor response group (P<0.005). The group in which both FeNO and blood eosinophils were suppressed fulfilled the change in score of 0.5 on the ACQ. ConclusionsIn the patients with severe asthma, responses to systemic corticosteroids were variable in terms of FeNO and blood eosinophils. It was necessary to suppress both persistent eosinophilia and high FeNO for the improvement of asthma control.

引用

页码：261 / 264

页数：4

共 9 条

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Asthma phenotypes and the use of biologic medications in asthma and allergic disease: The next steps toward personalized care [J].