Heteromultimeric CLC chloride channels with novel properties

被引：210

作者：

Lorenz, L ^{[1
]}

Pusch, M ^{[1
]}

Jentsch, TJ ^{[1
]}

机构：

[1] UNIV HAMBURG, CTR MOL NEUROBIOL, D-20246 HAMBURG, GERMANY

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1996年 / 93卷 / 23期

关键词：

anion channel; multimers; myotonia; cystic fibrosis; cell volume regulation;

D O I：

10.1073/pnas.93.23.13362

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The skeletal muscle chloride channel CLC-1 and the ubiquitous volume-activated chloride channel CLC-2 belong to a large gene family whose members often show overlapping expression patterns. CLC-1 and CLC-2 are coexpressed in skeletal and smooth muscle and in the heart. By coexpressing CLC-1 and CLC-2 in Xenopus oocytes, we now show the formation of novel CLC-1/CLC-2 heterooligomers that yield time-independent linear chloride currents with a chloride --> bromide --> iodide selectivity sequence. Formation of heterooligomeric CLC channels increases the number and possible functions of chloride channels.

引用

页码：13362 / 13366

页数：5

共 44 条

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