Cardiovascular risk factors in chronic kidney disease: does phosphate qualify?

被引：40

作者：

Hruska, Keith ^{[1
]}

Mathew, Suresh ^{[1
]}

Lund, Richard ^{[2
]}

Fang, Yifu ^{[1
]}

Sugatani, Toshifumi ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Pediat, Div Renal, St Louis, MO 63110 USA

[2] Creighton Univ, Dept Med, Omaha, NE 68178 USA

来源：

KIDNEY INTERNATIONAL | 2011年 / 79卷

基金：

美国国家卫生研究院;

关键词：

arterial calcification; cardiovascular disease; mortality; phosphate; CHRONIC RENAL-DISEASE; VASCULAR CALCIFICATION; SERUM PHOSPHORUS; HEMODIALYSIS-PATIENTS; MORTALITY RISK; CALCIUM; ASSOCIATION; SEVELAMER; PEOPLE;

D O I：

10.1038/ki.2011.24

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

100201 [内科学]; 100221 [泌尿外科学];

摘要：

Risk factors for disease states are rigorously defined. This analysis considers the definition of a risk factor as applied to the question of whether the serum phosphorus level is a risk factor for cardiovascular disease. Observational studies strongly suggest that phosphorus is associated with cardiovascular risk, and definitive prospective animal studies are supportive. A plausible mechanism of action has been discovered demonstrating that phosphorus stimulates osteoblastic transition of cells in the neointima of atherosclerotic plaques, which, if prevented, blocks vascular calcification. However, prospective studies demonstrating that modulation of the putative risk factor affects clinical outcomes are lacking, and phosphorus, as yet, does not qualify as a cardiovascular risk factor. This is a clarion call for additional research. Kidney International (2011) 79 (Suppl 121), S9-S13; doi:10.1038/ki. 2011.24; published online 23 February 2011

引用

页码：S9 / S13

页数：5

共 25 条

[1]

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